公开(公告)号：US11207323B2

公开(公告)日：2021-12-28

申请号：US16817830

申请日：2020-03-13

Applicant: Cyclerion Therapeutics, Inc.

Inventor： Takashi Nakai ,  Joel Moore ,  Nicholas Robert Perl ,  Rajesh R. Iyengar ,  Ara Mermerian ,  G-Yoon Jamie Im ,  Thomas Wai-Ho Lee ,  Colleen Hudson ,  Glen Robert Rennie ,  Lei Jia ,  Paul Allan Renhowe ,  Timothy Claude Barden ,  Xiang Y. Yu ,  James Edward Sheppeck ,  Karthik Iyer ,  Joon Jung ,  George Todd Milne ,  Kimberly Kafadar Long ,  Mark G. Currie

IPC: A61K31/506 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D403/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D401/14 ,  C07D471/08 ,  C07D471/10 ,  A61K45/06 ,  C07D451/02 ,  A61K31/519

Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

公开(公告)号：US20200316065A1

公开(公告)日：2020-10-08

申请号：US16817830

申请日：2020-03-13

Applicant: Cyclerion Therapeutics, Inc.

Inventor： Takashi Nakai ,  Joel Moore ,  Nicholas Robert Perl ,  Rajesh R. Iyengar ,  Ara Mermerian ,  G-Yoon Jamie Im ,  Thomas Wai-Ho Lee ,  Colleen Hudson ,  Glen Robert Rennie ,  Lei Jia ,  Paul Allan Renhowe ,  Timothy Claude Barden ,  Xiang Y. Yu ,  James Edward Sheppeck ,  Karthik Iyer ,  Joon Jung ,  George Todd Milne ,  Kimberly Kafadar Long ,  Mark G. Currie

IPC: A61K31/506 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D403/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D401/14 ,  C07D471/08 ,  C07D471/10 ,  A61K45/06 ,  C07D451/02

Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

公开(公告)号：US10517874B2

公开(公告)日：2019-12-31

申请号：US15406959

申请日：2017-01-16

Applicant: Cyclerion Therapeutics, Inc.

Inventor： Takashi Nakai ,  Joel Moore ,  Nicholas Robert Perl ,  Rajesh R. Iyengar ,  Ara Mermerian ,  G-Yoon Jamie Im ,  Thomas Wai-Ho Lee ,  Colleen Hudson ,  Glen Robert Rennie ,  Paul Allan Renhowe ,  Timothy Claude Barden ,  Xiang Y. Yu ,  James Edward Sheppeck ,  Karthik Iyer ,  Joon Jung ,  George Todd Milne ,  Kimberly Kafadar Long ,  Mark G. Currie ,  James Jia

IPC: A61K31/506 ,  A61K45/06 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D403/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D401/14 ,  C07D471/08 ,  C07D471/10 ,  C07D451/02

Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.