-
公开(公告)号：US10858363B2
公开(公告)日：2020-12-08
申请号：US16273557
申请日：2019-02-12
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Glen Robert Rennie , Rajesh R. Iyengar , Thomas Wai-Ho Lee , Takashi Nakai , Ara Mermerian , Lei Jia , G-Yoon Jamie Im , Paul Allan Renhowe , Joon Jung , Peter Germano , Karthik Iyer , Timothy Claude Barden , Kim Tang
IPC: C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/52 , C07D471/04 , C07D473/00
Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I:
-
公开(公告)号：US20190248794A1
公开(公告)日：2019-08-15
申请号：US16273557
申请日：2019-02-12
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Glen Robert Rennie , Rajesh R. Iyengar , Thomas Wai-Ho Lee , Takashi Nakai , Ara Mermerian , Lei Jia , G-Yoon Jamie Im , Paul Allan Renhowe , Joon Jung , Peter Germano , Karthik Iyer , Timothy Claude Barden , Kim Tang
IPC: C07D487/04 , C07D473/00 , C07D471/04 , A61K31/437 , A61K31/4985 , A61K31/52
CPC classification number: C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/52 , C07D471/04 , C07D473/00
Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I:
-
公开(公告)号：US20220017515A1
公开(公告)日：2022-01-20
申请号：US17485858
申请日：2021-09-27
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Glen Robert Rennie , Timothy Claude Barden , Thomas Wai-Ho Lee , Rajesh R. Iyengar , Takashi Nakai , Ara Mermerian , Lei Jia , Karthik Iyer , G-Yoon Jamie Im , Paul Allan Renhowe , Joon Jung , Peter Germano , Kim Tang
IPC: C07D471/04 , C07D403/04 , C07D403/14 , C07D487/04
Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula I:
-
公开(公告)号：US11180493B2
公开(公告)日：2021-11-23
申请号：US16348377
申请日：2017-11-07
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Glen Robert Rennie , Timothy Claude Barden , Thomas Wai-Ho Lee , Rajesh R. Iyengar , Takashi Nakai , Ara Mermerian , Lei Jia , Karthik Iyer , G-Yoon Jamie Im , Paul Allan Renhowe , Joon Jung , Peter Germano , Kim Tang
IPC: C07D471/04 , C07D403/04 , C07D403/14 , C07D487/04
Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).
-
公开(公告)号：US11207323B2
公开(公告)日：2021-12-28
申请号：US16817830
申请日：2020-03-13
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Takashi Nakai , Joel Moore , Nicholas Robert Perl , Rajesh R. Iyengar , Ara Mermerian , G-Yoon Jamie Im , Thomas Wai-Ho Lee , Colleen Hudson , Glen Robert Rennie , Lei Jia , Paul Allan Renhowe , Timothy Claude Barden , Xiang Y. Yu , James Edward Sheppeck , Karthik Iyer , Joon Jung , George Todd Milne , Kimberly Kafadar Long , Mark G. Currie
IPC: A61K31/506 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D403/04 , C07D487/10 , C07D491/107 , C07D498/04 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D401/14 , C07D471/08 , C07D471/10 , A61K45/06 , C07D451/02 , A61K31/519
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
-
Patent Agency Ranking
公开(公告)号：US20210214364A1
公开(公告)日：2021-07-15
申请号：US17122542
申请日：2020-12-15
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Paul Allan Renhowe , James Edward Sheppeck , Takashi Nakai , Karthik Iyer , Nicholas Robert Perl , Glen Robert Rennie , Mark G. Currie , Kimberly Kafadar Long , George Todd Milne , Rajesh R. Iyengar
IPC: C07D487/04 , C07D405/14 , C07D405/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present patent application discloses at least the compounds according to Formula l shown below, or pharmaceutically acceptable salts thereof, wherein ringjB,n, JD, J,0, X, X1, J, RC, and W are as defined herein. These compounds are useful as simulators of soluble sGC.
-
公开(公告)号：US20200316065A1
公开(公告)日：2020-10-08
申请号：US16817830
申请日：2020-03-13
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Takashi Nakai , Joel Moore , Nicholas Robert Perl , Rajesh R. Iyengar , Ara Mermerian , G-Yoon Jamie Im , Thomas Wai-Ho Lee , Colleen Hudson , Glen Robert Rennie , Lei Jia , Paul Allan Renhowe , Timothy Claude Barden , Xiang Y. Yu , James Edward Sheppeck , Karthik Iyer , Joon Jung , George Todd Milne , Kimberly Kafadar Long , Mark G. Currie
IPC: A61K31/506 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D403/04 , C07D487/10 , C07D491/107 , C07D498/04 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D401/14 , C07D471/08 , C07D471/10 , A61K45/06 , C07D451/02
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
-
公开(公告)号：US20200071318A1
公开(公告)日：2020-03-05
申请号：US16348377
申请日：2017-11-07
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Glen Robert Rennie , Timothy Claude Barden , Thomas Wai-Ho Lee , Rajesh R. Iyengar , Takashi Nakai , Ara Mermerian , Lei Jia , Karthik Iyer , G-Yoon Jamie Im , Paul Allan Renhowe , Joon Jung , Peter Germano , Kim Tang
IPC: C07D471/04 , C07D403/04 , C07D403/14 , C07D487/04
Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).
-
公开(公告)号：US20210221793A1
公开(公告)日：2021-07-22
申请号：US17143933
申请日：2021-01-07
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Timothy Claude Barden , James Edward Sheppeck , Glen Robert Rennie , Paul Allan Renhowe , Nicholas Robert Perl , Takashi Nakai , Ara Mermerian , Thomas Wai-Ho Lee , Joon Jung , Lei Jia , Karthik Iyer , Rajesh R. Iyengar , G-Yoon Jamie Im
IPC: C07D403/04 , C07D401/14 , C07D413/14 , C07D403/14 , C07D417/14 , C07D487/04 , C07D491/10 , C07D495/04 , C07D491/107
Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
-
公开(公告)号：US10517874B2
公开(公告)日：2019-12-31
申请号：US15406959
申请日：2017-01-16
Applicant: Cyclerion Therapeutics, Inc.
Inventor： Takashi Nakai , Joel Moore , Nicholas Robert Perl , Rajesh R. Iyengar , Ara Mermerian , G-Yoon Jamie Im , Thomas Wai-Ho Lee , Colleen Hudson , Glen Robert Rennie , Paul Allan Renhowe , Timothy Claude Barden , Xiang Y. Yu , James Edward Sheppeck , Karthik Iyer , Joon Jung , George Todd Milne , Kimberly Kafadar Long , Mark G. Currie , James Jia
IPC: A61K31/506 , A61K45/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D403/04 , C07D487/10 , C07D491/107 , C07D498/04 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D401/14 , C07D471/08 , C07D471/10 , C07D451/02
Abstract: Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.048 seconds)
