公开(公告)号：US10293058B2

公开(公告)日：2019-05-21

申请号：US15136295

申请日：2016-04-22

Applicant: CureVac AG

Inventor： Mariola Fotin-Mleczek ,  Aleksandra Kowalczyk ,  Regina Heidenreich ,  Patrick Baumhof ,  Jochen Probst ,  Karl-Josef Kallen

IPC: C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K38/19 ,  A61K38/20 ,  C12N15/117 ,  A61K9/00 ,  A61K38/17 ,  A61K39/145 ,  A61K39/39 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12N7/00 ,  C07K16/34 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases.

公开(公告)号：US20190151469A1

公开(公告)日：2019-05-23

申请号：US16267063

申请日：2019-02-04

Applicant: CureVac AG

Inventor： Mariola Fotin-Mleczek ,  Aleksandra Kowalczyk ,  Regina Heidenreich ,  Patrick Baumhof ,  Jochen Probst ,  Karl-Josef Kallen

IPC: A61K48/00 ,  A61K38/17 ,  A61K39/39 ,  C07K16/30 ,  C07K16/28 ,  A61K39/395 ,  A61K39/145 ,  A61K38/19 ,  A61K38/20 ,  A61K39/12 ,  C12N7/00 ,  C07K16/34 ,  C12N15/117 ,  A61K45/06 ,  A61K9/00

Abstract: The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases.

公开(公告)号：US10918740B2

公开(公告)日：2021-02-16

申请号：US16039988

申请日：2018-07-19

Applicant: CureVac AG

Inventor： Mariola Fotin-Mleczek ,  Aleksandra Kowalczyk ,  Regina Heidenreich ,  Patrick Baumhof ,  Jochen Probst ,  Karl-Josef Kallen

IPC: C07H21/04 ,  A61K48/00 ,  A61K38/19 ,  A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/34 ,  A61K39/12 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/117 ,  A61K9/00 ,  A61K38/17 ,  A61K39/145 ,  A61K39/39 ,  A61K45/06 ,  C07K16/30 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases.

公开(公告)号：US10988754B2

公开(公告)日：2021-04-27

申请号：US16026729

申请日：2018-07-03

Applicant: CureVac AG

Inventor： Mariola Fotin-Mleczek ,  Katja Fiedler ,  Aleksandra Kowalczyk ,  Regina Heidenreich

IPC: A61K48/00 ,  A61K39/00 ,  C12N9/90 ,  C07K14/705 ,  A61K39/39 ,  A61K39/385 ,  A61K38/00

Abstract: The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.

公开(公告)号：US20190040378A1

公开(公告)日：2019-02-07

申请号：US16026729

申请日：2018-07-03

Applicant: CureVac AG

Inventor： Mariola Fotin-Mleczek ,  Katja Fiedler ,  Aleksandra Kowalczyk ,  Regina Heidenreich

IPC: C12N9/90

Abstract: The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.