公开(公告)号：US20240050470A1

公开(公告)日：2024-02-15

申请号：US18489703

申请日：2023-10-18

申请人： Corvitus LLC ,  Corvitus GmbH

发明人： Tracy Goeken ,  Bernard Winkler

IPC分类号： A61K33/42 ,  A61K33/06 ,  A61K38/06 ,  A61K33/14 ,  A61K31/7004 ,  A61K31/375 ,  A61K31/198 ,  A61K31/205 ,  A61P9/10 ,  A61K9/00

CPC分类号： A61K33/42 ,  A61K33/06 ,  A61K38/063 ,  A61K33/14 ,  A61K31/7004 ,  A61K31/375 ,  A61K31/198 ,  A61K31/205 ,  A61P9/10 ,  A61K9/0019

摘要： A method to inhibit reperfusion injury to a tissue that has experienced ischemia comprising treating the ischemic tissue with an antioxidant solution prior to or in conjunction with reperfusion of blood into the ischemic tissue pursuant to artery bypass surgery, angioplasty or in conjunction with an angiogram. The antioxidant solution is comprised of water, dissolved salts of calcium, potassium, magnesium, sodium, one or more buffers, L-Arginine, glucose, glutathione, and ascorbic acid and wherein the solution is ionically and pH balanced to a physiologic pH, preferably 7.2-7.4.