公开(公告)号：US20230277617A1

公开(公告)日：2023-09-07

申请号：US18054587

申请日：2022-11-11

Applicant: ContraFect Corporation

Inventor： Raymond SCHUCH ,  Robert C. NOWINSKI ,  Michael WITTEKIND ,  Babar KHAN ,  Jimmy ROTOLO

IPC: A61K38/16 ,  C12N9/50 ,  A01N63/50 ,  A61L29/08 ,  A61L29/16 ,  C07K14/315 ,  A61K38/47 ,  A61K45/06

CPC classification number: A61K38/16 ,  C12N9/503 ,  A01N63/50 ,  A61K38/164 ,  A61L29/08 ,  A61L29/16 ,  C07K14/315 ,  A61K38/47 ,  A61K45/06 ,  C12Y302/01017 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2420/00

Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphylococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

公开(公告)号：US20190387745A1

公开(公告)日：2019-12-26

申请号：US16391272

申请日：2019-04-22

Applicant: ContraFect Corporation

Inventor： Raymond SCHUCH ,  Robert C. NOWINSKI ,  Michael WITTEKIND ,  Babar KHAN ,  Jimmy ROTOLO

IPC: A01N63/00 ,  C07K14/315 ,  A61L29/16 ,  A61L29/08 ,  A61K45/06 ,  A61K38/47 ,  A61K38/16 ,  C12N9/50

Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.