公开(公告)号：US20170159035A1

公开(公告)日：2017-06-08

申请号：US15434879

申请日：2017-02-16

申请人： Codexis, Inc.

发明人： Jie Yang ,  Xiyun Zhang ,  Jungjoo Yoon ,  Kripa K. Rao ,  John H. Grate ,  David M. Elgart ,  Dipnath Baidyaroy

IPC分类号： C12N9/42

CPC分类号： C12N9/2434 ,  C12N9/242 ,  C12N9/2437 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/14 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16

摘要： The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.

公开(公告)号：US20150010981A1

公开(公告)日：2015-01-08

申请号：US14496979

申请日：2014-09-25

申请人： Codexis, Inc.

发明人： Jie Yang ,  Xiyun Zhang ,  Jungjoo Yoon ,  Kripa K. Rao ,  John H. Grate ,  David M. Elgart ,  Dipnath Baidyaroy

IPC分类号： C12N9/42 ,  C12N9/30

CPC分类号： C12N9/2434 ,  C12N9/242 ,  C12N9/2437 ,  C12N9/2445 ,  C12P7/10 ,  C12P19/14 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16

摘要： The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.

摘要翻译： 本发明提供了包含各种氨基酸取代的各种GH61蛋白质变体。 GH61蛋白质变体具有改善的与纤维素酶协同作用的能力，从而提高通过生物质糖化获得的可发酵糖的产量。 在一些实施方案中，从糖化获得的糖被发酵以产生许多终产物，包括但不限于醇。