公开(公告)号：US20240229034A1

公开(公告)日：2024-07-11

申请号：US18285964

申请日：2022-04-06

申请人： City of Hope

发明人： Kevin Morris ,  Alicia Davis ,  Tristan Scott ,  Roslyn Ray ,  Denis O'Meally

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K47/69

CPC分类号： C12N15/1131 ,  A61K31/7105 ,  A61K47/6925 ,  C12N2310/14

摘要： Provided herein are, inter alia, lipid nanoparticles, lipid nanoparticles comprising nucleic acids encapsulated therein, pharmaceutical compositions comprising lipid nanoparticles which comprise nucleic acids encapsulated therein, and methods of treating diseases, such as coronavirus infections (e.g., SARS-CoV-2, SARS-CoV-2, MERS-CoV), COVID, and MERS.