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    Composition For Treatment Of Articular Cartilage Damage
    1.
    发明申请
    Composition For Treatment Of Articular Cartilage Damage 审中-公开
    关节软骨损伤治疗组合物

    公开(公告)号：US20090047261A1

    公开(公告)日：2009-02-19

    申请号：US12237225

    申请日：2008-09-24

    申请人： Chul-Won HA ,  Yoon-sun Yang ,  Sung-Eun Yang

    发明人： Chul-Won HA ,  Yoon-sun Yang ,  Sung-Eun Yang

    IPC分类号： A61K35/12

    CPC分类号： A61K35/28 ,  A61K35/51 ,  Y02A50/411

    摘要： Disclosed is a composition for the treatment of cartilage or bone damage or loss or defect. The composition comprises mesenchymal stem cells separated from umbilical cord blood and/or mesenchymal stem cells proliferated and/or differentiated. The composition also comprise chondrocytes and/or chondroblasts, or osteocytes and/or osteoblasts, differentiated from the mesenchymal stem cells separated from the umbilical cord blood.

    摘要翻译： 公开了用于治疗软骨或骨损伤或损失或缺陷的组合物。 该组合物包含从脐带血和/或间充质干细胞分离的间充质干细胞增殖和/或分化。 组合物还包括与从脐带血分离的间充质干细胞分化的软骨细胞和/或软骨细胞，或骨细胞和/或成骨细胞。

    Isolation and Culture-Expansion Methods of Mesenchymal Stem/Progenitor Cells From Umbilical Cord Blood, And Differentiation Method of Umbilical Cord Blood-Derived Meschymal Stem/Progenitor Cells Into Various Mesenchymal Tissues
    2.
    发明申请
    Isolation and Culture-Expansion Methods of Mesenchymal Stem/Progenitor Cells From Umbilical Cord Blood, And Differentiation Method of Umbilical Cord Blood-Derived Meschymal Stem/Progenitor Cells Into Various Mesenchymal Tissues 审中-公开
    脐带血间充质干/祖细胞的分离培养扩增方法及脐带血衍生的间充质干/祖细胞分化成各种间质组织

    公开(公告)号：US20100184218A1

    公开(公告)日：2010-07-22

    申请号：US12579140

    申请日：2009-10-14

    申请人： Chul-Won HA ,  Yoon-Sun Yang ,  Sung-Eun Yang

    发明人： Chul-Won HA ,  Yoon-Sun Yang ,  Sung-Eun Yang

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0665 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/42 ,  C12N2501/15

    摘要： There is provided a method for the isolation and cultivation of mesenchymal stem/progenitor cells from umbilical cord blood, and also to a method for the differentiation of the umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues. The method include overlaying umbilical cord blood onto Ficoll-Hypaque solution; centrifuging the umbilical cord blood on the Ficoll-Hypaque solution to obtain a mononuclear cell layer; reacting cells obtained by monolayer culture of the mononuclear cells with antibodies to mesenchymal stem/progenitor cell-specific antigens for a predetermined period of incubation time; isolating only cells bound to their corresponding antibodies using a cell sorter; and cultivating the isolated cells, thereby obtaining mesenchymal stem/progenitor cells with high purity and excellent viability.

    摘要翻译： 提供了从脐带血分离和培养间充质干/祖细胞的方法，以及将脐带血来源的间充质干/祖细胞分化成各种间充质组织的方法。 该方法包括将脐带血覆盖在Ficoll-Hypaque溶液上; 在Ficoll-Hypaque溶液上离心脐带血，获得单核细胞层; 将单核细胞的单层培养获得的细胞与间充质干/祖细胞特异性抗原的抗体反应预定的孵育时间; 使用细胞分选器分离仅与其相应抗体结合的细胞; 并培养分离的细胞，从而获得高纯度和优良活力的间充质干细胞/祖细胞。