公开(公告)号：US20180036387A1

公开(公告)日：2018-02-08

申请号：US15619125

申请日：2017-06-09

Applicant: Chiesi Farmaceutici S.p.A

Inventor： Jens Fogh ,  Claes Andersson ,  Cecilia Weigelt ,  Pia Hydén ,  Helena Reuterwall ,  Stefan Nilsson

IPC: A61K38/47

CPC classification number: A61K38/47 ,  A61K38/00 ,  C12N9/2488 ,  C12Y302/01024

Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.

公开(公告)号：US10159718B2

公开(公告)日：2018-12-25

申请号：US15619125

申请日：2017-06-09

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Jens Fogh ,  Claes Andersson ,  Cecilia Weigelt ,  Pia Hydén ,  Helena Reuterwall ,  Stefan Nilsson

IPC: A61K38/00 ,  A61K38/47 ,  C12N9/24

Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.

公开(公告)号：US20170202927A1

公开(公告)日：2017-07-20

申请号：US15473460

申请日：2017-03-29

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Stefan Nilsson

IPC: A61K38/45 ,  C12N9/10

CPC classification number: A61K38/45 ,  A61K38/465 ,  A61K38/47 ,  C07K1/34 ,  C07K1/36 ,  C12N9/1085 ,  C12Y205/01061 ,  C12Y301/06001 ,  C12Y301/06008 ,  C12Y302/01024 ,  C12Y302/01046

Abstract: The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals, in particular by subcutaneous injection.