公开(公告)号：US20180036387A1

公开(公告)日：2018-02-08

申请号：US15619125

申请日：2017-06-09

Applicant: Chiesi Farmaceutici S.p.A

Inventor： Jens Fogh ,  Claes Andersson ,  Cecilia Weigelt ,  Pia Hydén ,  Helena Reuterwall ,  Stefan Nilsson

IPC: A61K38/47

CPC classification number: A61K38/47 ,  A61K38/00 ,  C12N9/2488 ,  C12Y302/01024

Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.

公开(公告)号：US10159718B2

公开(公告)日：2018-12-25

申请号：US15619125

申请日：2017-06-09

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Jens Fogh ,  Claes Andersson ,  Cecilia Weigelt ,  Pia Hydén ,  Helena Reuterwall ,  Stefan Nilsson

IPC: A61K38/00 ,  A61K38/47 ,  C12N9/24

Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.

公开(公告)号：US09986722B2

公开(公告)日：2018-06-05

申请号：US14418038

申请日：2013-08-07

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Jens Fogh ,  Claes Andersson

IPC: A01K67/027 ,  C12N9/24 ,  A61K49/00 ,  C12N15/85

CPC classification number: A01K67/0278 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K49/0008 ,  C12N9/2402 ,  C12N15/8509 ,  C12Y302/01046

Abstract: The present invention relates to an animal model for infantile globoid cell leucodystrophy, and use of said animal model for screening and/or validation of agents which may be useful as a medicament for treatment of globoid cell leukodystrophy.

公开(公告)号：US20180112202A1

公开(公告)日：2018-04-26

申请号：US15821223

申请日：2017-11-22

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Jens Fogh ,  Claes Andersson ,  Pia Hydén ,  Pia Ringholm Gulstad ,  Kerstin Lundell ,  Magnus Hjertman

IPC: C12N9/24 ,  A61P5/00

CPC classification number: C12N9/2402 ,  A61K38/00 ,  A61P5/00 ,  C12Y302/01046

Abstract: The present invention relates to a process for purifying recombinant human Galactocerebroside β-Galactosidase (rhGALC) from a cell culture, wherein a fraction of said cell culture comprising rhGALC is subjected to chromatography on three distinct resins.