公开(公告)号：US20240294618A1

公开(公告)日：2024-09-05

申请号：US18481129

申请日：2023-10-04

Applicant: Centivax, Inc.

Inventor： Jacob E. Glanville ,  Timothy Paul Friede ,  David Tsao ,  Sindy Andrea Liao Chan ,  I-Chieh Wang

IPC: C07K16/18 ,  A61K31/404 ,  A61K39/00 ,  A61P39/02 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K31/404 ,  A61P39/02 ,  G01N33/6857 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76 ,  G01N2333/4616 ,  G01N2333/4646

Abstract: This disclosure provides antibodies and antigen-binding fragments that can be administered to a subject that has been bitten by a venomous snake. Antibodies and antigen-binding fragments herein can be capable of treating or curing the subject and may provide protection against snake venom for up to several weeks. A combination or population of antibodies and antigen-binding fragments can be administered to the subject where the type of snake is not known or where a subject has been bitten by more than one species of snake. This disclosure further provides methods for identification of such broadly-neutralizing antibodies.