-
公开(公告)号：US20240327381A1
公开(公告)日：2024-10-03
申请号：US18435117
申请日：2024-02-07
IPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/00 , C07D471/04
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/00 , C07D471/04
摘要： Provided herein are compounds and compositions thereof for degrading an engineered polypeptide in a cell. In some embodiments, the compounds and compositions are provided for treatment of cancer.
-
公开(公告)号：US10335495B2
公开(公告)日：2019-07-02
申请号：US15532255
申请日：2015-12-03
申请人： CELGENE CORPORATION
IPC分类号： A61K31/5365 , A61K47/68 , A61K47/54 , A61K47/60
摘要： The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the structure of the biomolecule and wherein the NNAA is a point of attachment of a linker to which a payload, particularly a cytotoxic agent, is attached. More specifically, this invention relates to conjugates of cell-binding agents and active release products comprising cytotoxic agents wherein the conjugates are produced by means of a cycloaddition reaction. Methods of production, pharmaceutical compositions and methods of use are provided.
-
公开(公告)号：US20230095912A1
公开(公告)日：2023-03-30
申请号：US17817777
申请日：2022-08-05
申请人： Celgene Corporation
发明人： Christopher Walton Carroll , Laura Akullian D'Agostino , Haibo Liu , Veerabahu Shanmugasundaram , Brook Barajas
IPC分类号： C07K14/47 , C07K14/725
摘要： The present disclosure relates to engineered polypeptides comprising degradation domains, compounds, compositions, and methods for their preparation and use as for degrading engineered proteins in cells.
-
公开(公告)号：US20170360952A1
公开(公告)日：2017-12-21
申请号：US15532255
申请日：2015-12-03
申请人： CELGENE CORPORATION
IPC分类号： A61K47/68 , A61K47/54 , A61K47/60 , A61K31/5365
CPC分类号： A61K47/6803 , A61K31/5365 , A61K47/545 , A61K47/60 , A61K47/6835 , A61K47/6889
摘要： The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the structure of the biomolecule and wherein the NNAA is a point of attachment of a linker to which a payload, particularly a cytotoxic agent, is attached. More specifically, this invention relates to conjugates of cell-binding agents and active release products comprising cytotoxic agents wherein the conjugates are produced by means of a cycloaddition reaction. Methods of production, pharmaceutical compositions and methods of use are provided.
-
-
-
搜索结果
4 条记录 (耗时 0.023 秒)
