公开(公告)号：US20200271650A1

公开(公告)日：2020-08-27

申请号：US16734842

申请日：2020-01-06

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/573 ,  C07K16/12 ,  A61K39/02 ,  G01N33/68

摘要： The present invention describes methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering CDT inhibitors and/or CDT neutralizers to a subject in need thereof. The present invention also describes methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS. The present invention further describes methods of diagnosing IBS by detecting the presence or absence of CDT or a CDT marker in a subject.

公开(公告)号：US20200087711A1

公开(公告)日：2020-03-19

申请号：US16694845

申请日：2019-11-25

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Ruchi Mathur ,  Christopher Chang

IPC分类号： C12Q1/689 ,  A61K31/4164 ,  A61K31/155 ,  A61K31/437 ,  A61K35/741 ,  A61K45/06 ,  A61K31/137 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/337 ,  A61K31/351 ,  A61K31/357 ,  A61K31/55

摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

公开(公告)号：US10466254B2

公开(公告)日：2019-11-05

申请号：US15922604

申请日：2018-03-15

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/68 ,  G01N33/564 ,  A61K38/17

摘要： Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.

公开(公告)号：US09952223B2

公开(公告)日：2018-04-24

申请号：US15609959

申请日：2017-05-31

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/68 ,  A61K38/17

CPC分类号： G01N33/6887 ,  A61K38/1709 ,  G01N33/564 ,  G01N2333/4703 ,  G01N2333/705 ,  G01N2800/06 ,  G01N2800/065 ,  G01N2800/2842

摘要： Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.

公开(公告)号：US20160038562A1

公开(公告)日：2016-02-11

申请号：US14776465

申请日：2014-03-14

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： Mark Pimentel ,  Ruchi Mathur ,  Christopher Chang

IPC分类号： A61K38/10 ,  C12Q1/68 ,  A61K31/405 ,  A61K31/366 ,  A61K31/47 ,  A61K31/22 ,  A61K31/505 ,  A61K31/137 ,  A61K31/357 ,  A61K31/337 ,  A61K31/55 ,  A61K31/454 ,  A61K38/28 ,  A61K31/426 ,  A61K31/4525 ,  A61K31/4045 ,  A61K31/352 ,  A61K31/155 ,  A61K31/40

CPC分类号： A61K38/10 ,  A61K31/137 ,  A61K31/155 ,  A61K31/22 ,  A61K31/337 ,  A61K31/352 ,  A61K31/357 ,  A61K31/366 ,  A61K31/40 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/55 ,  A61K31/7028 ,  A61K38/14 ,  A61K38/26 ,  A61K38/28 ,  C12Q1/689 ,  C12Q2600/106 ,  A61K2300/00

摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

公开(公告)号：US12071673B2

公开(公告)日：2024-08-27

申请号：US16694845

申请日：2019-11-25

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Ruchi Mathur ,  Christopher Chang

IPC分类号： C12Q1/689 ,  A61K31/137 ,  A61K31/155 ,  A61K31/22 ,  A61K31/337 ,  A61K31/351 ,  A61K31/357 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/55 ,  A61K31/7036 ,  A61K31/7048 ,  A61K35/741 ,  A61K45/06

CPC分类号： C12Q1/689 ,  A61K31/137 ,  A61K31/155 ,  A61K31/22 ,  A61K31/337 ,  A61K31/351 ,  A61K31/357 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/55 ,  A61K31/7036 ,  A61K31/7048 ,  A61K35/741 ,  A61K45/06 ,  C12Q2600/106 ,  A61K35/741 ,  A61K2300/00 ,  A61K31/155 ,  A61K2300/00 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/7036 ,  A61K2300/00 ,  A61K31/4164 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/404 ,  A61K2300/00 ,  A61K31/366 ,  A61K2300/00 ,  A61K31/47 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/505 ,  A61K2300/00 ,  A61K31/137 ,  A61K2300/00 ,  A61K31/7048 ,  A61K2300/00 ,  A61K31/454 ,  A61K2300/00

摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

公开(公告)号：US09851361B2

公开(公告)日：2017-12-26

申请号：US15021850

申请日：2014-10-09

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/065

摘要： The present invention describes methods, assays, and systems of diagnosing, selecting and treating irritable bowel syndrome (IBS) based on a subject's level of anti-vinculin and anti-CdtB antibodies. IBS can be distinguished from inflammatory bowel (IBD) disease using the methods, assays, and systems described herein.

公开(公告)号：US20160103136A1

公开(公告)日：2016-04-14

申请号：US14878416

申请日：2015-10-08

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  G01N2333/205 ,  G01N2800/065 ,  G01N2800/52

摘要： Described herein are methods and systems for distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-vinculin antibodies and anti-CdtB antibodies to distinguish IBS from IBD and celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.

摘要翻译： 本文描述了区分肠易激综合征（IBS）与炎症性肠病（IBD）和乳糜泻的方法和系统。 该方法和系统可以利用抗新戊环素抗体和抗CdtB抗体的检测来区分IBS与IBD和乳糜泻。 进一步描述的是选择治疗IBS，IBD或腹腔疾病的方法。

公开(公告)号：US10527621B2

公开(公告)日：2020-01-07

申请号：US16185955

申请日：2018-11-09

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Christopher Chang

IPC分类号： G01N33/573 ,  G01N33/68 ,  C07K16/12 ,  A61K39/02 ,  A61K39/00

摘要： The present invention describes methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering CDT inhibitors and/or CDT neutralizers to a subject in need thereof. The present invention also describes methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS. The present invention further describes methods of diagnosing IBS by detecting the presence or absence of CDT or a CDT marker in a subject.

公开(公告)号：US10519515B2

公开(公告)日：2019-12-31

申请号：US15810891

申请日：2017-11-13

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Ruchi Mathur ,  Christopher Chang

IPC分类号： C12Q1/689 ,  A61K31/4164 ,  A61K31/155 ,  A61K31/437 ,  A61K35/741 ,  A61K45/06 ,  A61K31/137 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/337 ,  A61K31/351 ,  A61K31/357 ,  A61K31/55

摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.