-
公开(公告)号：US11229809B2
公开(公告)日：2022-01-25
申请号：US15912359
申请日：2018-03-05
Applicant: California Institute of Technology
Inventor： David Reza Mittelstein , Morteza Gharib , Stefanie Heyden , Michael Ortiz , Mikhail G. Shapiro
Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at a resonance frequency (“oncotripsy”) for the specific cell types are presented. The systems and the methods result in permeabilization, lysis, and/or death of the targeted specific cell types by using ultrasonic harmonic excitations that have a frequency and a pulse duration specifically tuned to disrupt nuclear membranes of the targeted specific cell types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.
-
公开(公告)号：US20180256922A1
公开(公告)日：2018-09-13
申请号：US15912359
申请日：2018-03-05
Applicant: California Institute of Technology
Inventor： David Reza Mittelstein , Morteza Gharib , Stefanie Heyden , Michael Ortiz , Mikhail G. Shapiro
CPC classification number: A61N7/00 , A61B5/055 , A61B8/485 , A61B8/5261 , A61B17/3205 , A61B2017/00154 , A61B2018/00642 , A61B2018/0066 , A61B2018/00732 , A61B2090/374 , A61B2090/378 , A61M37/0092
Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the permeabilization, lysis, and/or death of targeted cell types by using ultrasonic harmonic excitations that have their frequency and pulse duration specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.
-
公开(公告)号：US20140371353A1
公开(公告)日：2014-12-18
申请号：US14308347
申请日：2014-06-18
Applicant: California Institute of Technology
Inventor： Stephanie Mitchell , Anna Pandolfi , Michael Ortiz
CPC classification number: C04B14/34 , C04B14/322 , C04B24/287 , C04B28/02 , C04B2111/2046 , E04B1/985 , E04H9/021 , G10K11/165 , C04B20/1037 , C04B20/1051 , C04B20/1033
Abstract: Materials and Methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force improving the dynamic performance of the metamaterial by impeding dynamic excitation. The engineered aggregate generally comprise a multilayer resonant structure having at least a relatively heavy inner core surrounded by at least a compliant coating layer. The geometry and stiffness of the relative layers can be tuned to engineer a desired resonant frequency response within the aggregate for a chosen frequency range. The engineered aggregates are disposed in a matrix material to form a metamaterial. The engineered aggregates may be disposed within a mortar matrix to form a concrete metamaterial suitable for use, for example, in structural applications, including bunkers, shelters, etc.
Abstract translation: 提供了在超材料中实施工程聚集体的材料和方法。 可以调整工程聚集体在外力的作用下共振地振荡，通过阻碍动态激发改善超材料的动态性能。 工程化骨料通常包括多层共振结构，其至少具有由至少柔顺涂层包围的至少相当重的内核。 可以调整相对层的几何形状和刚度，以在所选择的频率范围内在聚合体内设计所需的谐振频率响应。 将工程聚集体设置在基质材料中以形成超材料。 工程聚集体可以设置在砂浆基质内以形成适合于例如在结构应用中使用的混凝土超材料，包括沙坑，掩体等。
-
Patent Agency Ranking
公开(公告)号：US20170165506A1
公开(公告)日：2017-06-15
申请号：US15373916
申请日：2016-12-09
Applicant: California Institute of Technology
Inventor： Michael Ortiz , Stefanie Heyden
IPC: A61N7/00
CPC classification number: A61N7/00 , A61B17/225 , A61N2007/0004
Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the lysis of targeted cell types by using ultrasonic harmonic excitations that have been specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact, The target cells types may be cancerous cells.
-
公开(公告)号：US20160376192A1
公开(公告)日：2016-12-29
申请号：US15263157
申请日：2016-09-12
Applicant: California Institute of Technology
Inventor： Stephanie Mitchell , Anna Pandolfi , Michael Ortiz
CPC classification number: C04B14/34 , C04B14/322 , C04B24/287 , C04B28/02 , C04B2111/2046 , E04B1/985 , E04H9/021 , G10K11/165 , C04B20/1037 , C04B20/1051 , C04B20/1033
Abstract: Materials and methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force improving the dynamic performance of the metamaterial by impeding dynamic excitation. The engineered aggregate generally comprise a multilayer resonant structure having at least a relatively heavy inner core surrounded by at least a compliant coating layer. The geometry and stiffness of the relative layers can be tuned to engineer a desired resonant frequency response within the aggregate for a chosen frequency range. The engineered aggregates are disposed in a matrix material to form a metamaterial. The engineered aggregates may be disposed within a mortar matrix to form a concrete metamaterial suitable for use, for example, in structural applications, including bunkers, shelters, etc.
Abstract translation: 提供了在超材料中实现工程聚集体的材料和方法。 可以调整工程聚集体在外力的作用下共振地振荡，通过阻碍动态激发改善超材料的动态性能。 工程化骨料通常包括多层共振结构，其至少具有由至少柔顺涂层包围的至少相当重的内核。 可以调整相对层的几何形状和刚度，以在所选择的频率范围内在聚合体内设计所需的谐振频率响应。 将工程聚集体设置在基质材料中以形成超材料。 工程聚集体可以设置在砂浆基质内以形成适合于例如在结构应用中使用的混凝土超材料，包括掩体，掩体等。
-
公开(公告)号：US11097130B2
公开(公告)日：2021-08-24
申请号：US15373916
申请日：2016-12-09
Applicant: California Institute of Technology
Inventor： Michael Ortiz , Stefanie Heyden
IPC: A61N7/00
Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the lysis of targeted cell types by using ultrasonic harmonic excitations that have been specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. The target cells types may be cancerous cells.
-
公开(公告)号：US09464001B2
公开(公告)日：2016-10-11
申请号：US14308347
申请日：2014-06-18
Applicant: California Institute of Technology
Inventor： Stephanie Mitchell , Anna Pandolfi , Michael Ortiz
IPC: C04B14/34 , C04B28/02 , C04B14/32 , G10K11/165 , C04B111/20 , E04B1/98 , E04H9/02
CPC classification number: C04B14/34 , C04B14/322 , C04B24/287 , C04B28/02 , C04B2111/2046 , E04B1/985 , E04H9/021 , G10K11/165 , C04B20/1037 , C04B20/1051 , C04B20/1033
Abstract: Materials and methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force improving the dynamic performance of the metamaterial by impeding dynamic excitation. The engineered aggregate generally comprise a multilayer resonant structure having at least a relatively heavy inner core surrounded by at least a compliant coating layer. The geometry and stiffness of the relative layers can be tuned to engineer a desired resonant frequency response within the aggregate for a chosen frequency range. The engineered aggregates are disposed in a matrix material to form a metamaterial. The engineered aggregates may be disposed within a mortar matrix to form a concrete metamaterial suitable for use, for example, in structural applications, including bunkers, shelters, etc.
Abstract translation: 提供了在超材料中实现工程聚集体的材料和方法。 可以调整工程聚集体在外力的作用下共振地振荡，通过阻碍动态激发改善超材料的动态性能。 工程化骨料通常包括多层共振结构，其至少具有由至少柔顺涂层包围的至少相当重的内核。 可以调整相对层的几何形状和刚度，以在所选择的频率范围内在聚合体内设计所需的谐振频率响应。 将工程聚集体设置在基质材料中以形成超材料。 工程聚集体可以设置在砂浆基质内以形成适合于例如在结构应用中使用的混凝土超材料，包括掩体，掩体等。
-
8.发明申请公开(公告)号：US20140315093A1
公开(公告)日：2014-10-23
申请号：US14254824
申请日：2014-04-16
Applicant: California Institute of Technology
Inventor： Julia R. Greer , Michael Ortiz , Lucas R. Meza , Lauren C. Montemayor , Jiao Wu , Xun W. Gu
CPC classification number: H01M4/72 , H01G11/26 , H01G11/30 , H01M8/0247 , Y02E60/13
Abstract: A scaffold includes struts that intersect at nodes. In some instances, a cross section of the cores has at least one dimension less than 100 microns. The core can be a solid, liquid or a gas. In some instances, one or more shell layers are positioned on the core.
Abstract translation: 支架包括在节点处相交的支柱。 在一些情况下，芯的横截面具有至少一个小于100微米的尺寸。 核心可以是固体，液体或气体。 在一些情况下，一个或多个壳层位于芯上。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.017 seconds)
