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公开(公告)号：US10426961B2
公开(公告)日：2019-10-01
申请号：US15958985
申请日：2018-04-20
Applicant: Cyberonics, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
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公开(公告)号：US10166391B2
公开(公告)日：2019-01-01
申请号：US15805062
申请日：2017-11-06
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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3.发明申请公开(公告)号：US20180361158A1
公开(公告)日：2018-12-20
申请号：US16009099
申请日：2018-06-14
Applicant: Cyberonics, Inc. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell , Gregory A. Ordway
Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.
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公开(公告)号：US09950169B2
公开(公告)日：2018-04-24
申请号：US14262270
申请日：2014-04-25
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/36157 , A61N1/36171 , A61N1/3627
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
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5.发明授权公开(公告)号：US09713719B2
公开(公告)日：2017-07-25
申请号：US14255276
申请日：2014-04-17
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Bruce H. KenKnight , Imad Libbus , Badri Amurthur , Jeffrey L. Ardell
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36157 , A61N1/36171 , A61N1/3627
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.
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Patent Agency Ranking
6.发明申请RESPONSIVE NEUROSTIMULATION FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION 有权用于治疗慢性心脏功能障碍的反应性神经病学公开(公告)号：US20170001012A1
公开(公告)日：2017-01-05
申请号：US15267922
申请日：2016-09-16
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
Abstract translation: 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 识别神经支点区域，并在神经支点区域内递送正在进行的神经刺激治疗。 植入的刺激装置包括生理传感器，用于在延长的时间段内基于动态监测患者对神经刺激疗法的反应，以及控制系统，用于根据检测到的生理反应的变化调整刺激参数以维持神经支点区域中的刺激 刺激。
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公开(公告)号：US20160346549A1
公开(公告)日：2016-12-01
申请号：US15236039
申请日：2016-08-12
Applicant: CYBERONICS, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/36157 , A61N1/36171 , A61N1/3627
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
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公开(公告)号：US20180117333A1
公开(公告)日：2018-05-03
申请号：US15805062
申请日：2017-11-06
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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9.发明授权公开(公告)号：US09446237B2
公开(公告)日：2016-09-20
申请号：US14861390
申请日：2015-09-22
Applicant: CYBERONICS, INC. , East Tennessee State University
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
CPC classification number: A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
Abstract translation: 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 识别神经支点区域，并在神经支点区域内递送正在进行的神经刺激治疗。 植入的刺激装置包括生理传感器，用于在延长的时间段内基于动态监测患者对神经刺激疗法的反应，以及控制系统，用于根据检测到的生理反应的变化调整刺激参数以维持神经支点区域中的刺激 刺激。
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10.发明授权公开(公告)号：US10195438B2
公开(公告)日：2019-02-05
申请号：US15783941
申请日：2017-10-13
Applicant: CYBERONICS, INC. , EAST TENNESSEE STATE UNIVERSITY
Inventor： Imad Libbus , Badri Amurthur , Bruce H. KenKnight , Jeffrey L. Ardell
Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
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