公开(公告)号：US20190322969A1

公开(公告)日：2019-10-24

申请号：US16447453

申请日：2019-06-20

Applicant: Corning Incorporated

Inventor： Ye Fang ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Gregory Roger Martin ,  Kaitlyn Mary Matias ,  Michael Kurt Schaefer ,  Allison Jean Tanner

IPC: C12M1/32 ,  C12M1/04 ,  C12M3/06 ,  C12M1/26 ,  C12M1/00

Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.

公开(公告)号：US20170342363A1

公开(公告)日：2017-11-30

申请号：US15492690

申请日：2017-04-20

Applicant: Corning Incorporated

Inventor： Ye Fang ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Gregory Roger Martin ,  Kaitlyn Mary Matias ,  Michael Kurt Schaefer ,  Allison Jean Tanner

IPC: C12M1/32 ,  C12M3/06 ,  C12M1/26

CPC classification number: C12M23/12 ,  C12M1/268 ,  C12M3/065 ,  C12M23/02 ,  C12M23/24

Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.

公开(公告)号：US20210169085A1

公开(公告)日：2021-06-10

申请号：US17180157

申请日：2021-02-19

Applicant: CORNING INCORPORATED

Inventor： Dayue Jiang ,  Kaitlyn Mary Matias ,  Kevin Andrew Vasilakos ,  Jianguo Wang ,  Jie Wang

IPC: A01N59/20 ,  C08K3/40 ,  C11D3/48 ,  C08K13/02 ,  C09K9/00 ,  C03C14/00 ,  C03C4/00 ,  A41D31/30 ,  C09D7/40 ,  C09D5/02 ,  C09D5/14 ,  C08K3/22 ,  C09D7/61 ,  C08K3/015

Abstract: A method of making an antimicrobial composite article, including the steps: providing a matrix comprising a polymeric material; providing a plurality of second phase particles comprising an antimicrobial agent; melting the matrix to form a matrix melt; distributing the plurality of second phase particles in the matrix melt at a second phase volume fraction to form a composite melt; forming a composite article from the composite melt; and treating the composite article to form an antimicrobial composite article having an exterior surface comprising an exposed portion of the matrix and the plurality of second phase particles. The distributing step can employ an extrusion process. The forming a composite article step can employ an injection molding process. The treating step can employ abrading and plasma-treating the article to define the exterior surface.

公开(公告)号：US10959434B2

公开(公告)日：2021-03-30

申请号：US15769943

申请日：2016-10-20

Applicant: CORNING INCORPORATED

Inventor： Dayue Jiang ,  Kaitlyn Mary Matias ,  Kevin Andrew Vasilakos ,  Jianguo Wang ,  Jie Wang

IPC: C03C3/00 ,  A01N59/20 ,  C03C4/00 ,  C08K3/40 ,  C03C14/00 ,  C08K3/22 ,  C08K13/02 ,  C09K9/00 ,  C09D7/61 ,  C09D7/40 ,  C09D5/14 ,  C09D5/02 ,  C11D3/48 ,  A41D31/30 ,  C08K3/015

Abstract: A method of making an antimicrobial composite article, including the steps: providing a matrix comprising a polymeric material; providing a plurality of second phase particles comprising an antimicrobial agent; melting the matrix to form a matrix melt; distributing the plurality of second phase particles in the matrix melt at a second phase volume fraction to form a composite melt; forming a composite article from the composite melt; and treating the composite article to form an antimicrobial composite article having an exterior surface comprising an exposed portion of the matrix and the plurality of second phase particles. The distributing step can employ an extrusion process. The forming a composite article step can employ an injection molding process. The treating step can employ abrading and plasma-treating the article to define the exterior surface.

公开(公告)号：US20150147775A1

公开(公告)日：2015-05-28

申请号：US14547487

申请日：2014-11-19

Applicant: CORNING INCORPORATED

Inventor： Derek Michael Fiacco ,  Jeffrey Glenn Lynn ,  Kaitlyn Mary Matias ,  Florence Christine Monique Verrier ,  Ying Wei

IPC: C12Q1/20 ,  C12N1/20

CPC classification number: C12Q1/20 ,  C12N1/20 ,  G01N2333/21 ,  G01N2333/245 ,  G01N2333/265 ,  G01N2333/31

Abstract: A method that includes the steps: inoculating nutrient agar with bacterial stock to form a culture; incubating the culture to form a first incubated culture; incubating a portion of the first culture with nutrient agar to form a second culture; incubating a portion of the second culture to form a third culture; incubating the third culture to form an inoculated test plate; forming an inoculum by suspending bacteria from the inoculated test plate in a buffered test solution, adjusting the pH to ˜7 to 8, and adding organic soil at a concentration of approximately 10% to 30% by weight; inoculating a silver-containing surface region of a test carrier with a portion of the inoculum; incubating the inoculated test carrier; washing the test carrier in a neutralizing solution to form a residual test inoculum; and calculating the percent reduction in the number of surviving bacterial colonies in the residual test inoculum.

Abstract translation: 一种包括以下步骤的方法：用细菌储存培养营养琼脂以形成培养物; 孵育培养物以形成第一培养培养物; 将一部分第一培养物与营养琼脂孵育以形成第二培养物; 孵育一部分第二培养物以形成第三培养物; 培养第三培养物以形成接种的测试板; 通过将接种的测试板上的细菌悬浮在缓冲的测试溶液中，将pH调节至约7至8并加入浓度为约10重量％至30重量％的有机土壤来形成接种物; 用一部分接种物接种试验载体的含银表面区域; 培养接种的试验载体; 在中和溶液中洗涤测试载体以形成残留测试接种物; 并计算残留测试接种物中存活的细菌菌落数量的百分比减少。