公开(公告)号：US20220356475A1

公开(公告)日：2022-11-10

申请号：US17640647

申请日：2020-08-31

申请人： UNIVERSITA' DEGLI STUDI DI TORINO ,  CONSIGLIO NAZIONALE DELLE RICERCHE

发明人： Daniela TAVERNA ,  Lorena QUIRICO ,  Francesca ORSO ,  Vittorio DE FRANCISCIS ,  Carla Lucia ESPOSITO ,  Silvia CATUOGNO

IPC分类号： C12N15/115 ,  A61K9/00 ,  A61P35/00

摘要： A chimeric complex comprising a microRNA in combination with an aptamer for AXL receptor tyrosine kinase is provided. Use of the chimeric complex for targeted treatment of a tumor disease, in particular in a therapy affecting onset and/or progression of tumor metastasis is also provided.

公开(公告)号：US20230227832A1

公开(公告)日：2023-07-20

申请号：US18002213

申请日：2021-06-17

申请人： CONSIGLIO NAZIONALE DELLE RICERCHE

发明人： Vittorio DE FRANCISCIS ,  Gerolama CONDORELLI ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Cristina QUINTAVALLE ,  Francesco INGENITO

IPC分类号： C12N15/115 ,  C12N15/10 ,  C12Q1/6886

CPC分类号： C12N15/115 ,  C12N15/1048 ,  C12Q1/6886 ,  C12N2310/16

摘要： The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.

公开(公告)号：US20230167453A1

公开(公告)日：2023-06-01

申请号：US17995343

申请日：2021-04-01

申请人： Board of Regents, The University of Texas System ,  Consiglio Nazionale delle Ricerche

发明人： Anil K. SOOD ,  Paola AMERO ,  Gabriel LOPEZ-BERESTEIN ,  Vittorio DE FRANCISCIS

IPC分类号： C12N15/115 ,  A61P35/00

CPC分类号： C12N15/115 ,  A61P35/00 ,  C12N2310/16 ,  C12N2310/322

摘要： Provided herein are RNA aptamers targeting CD5L. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

公开(公告)号：US20220380766A1

公开(公告)日：2022-12-01

申请号：US17413550

申请日：2019-12-16

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM AKA ,  Consiglio Nazionale delle Ricerche

发明人： Gabriel LOPEZ-BERESTEIN ,  Paola AMERO ,  Cristian RODRIGUEZ-AGUAYO ,  Rahul MITRA ,  Anil K. SOOD ,  Vittorio DE FRANCISCIS ,  David VOLK ,  Lokesh Ganesh L. RAO

IPC分类号： C12N15/115 ,  A61K31/337 ,  A61K33/243 ,  A61P35/00

摘要： Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.