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1.
公开(公告)号:US12064492B2
公开(公告)日:2024-08-20
申请号:US16096505
申请日:2017-05-03
申请人: Consiglio Nazionale delle Ricerche , Plasma Diagnostics and Technologies S.r.l. , Universita degli Studi di Firenze
发明人: Angela Zoppi , Mario Del Rosso , Anna Laurenzana , Gabriella Fibbi , Francesca Margheri , Anastasia Chilla' , Giancarlo Margheri
IPC分类号: A61K9/00 , A61K33/242 , A61K35/28 , A61K41/00 , A61K47/69 , A61K49/00 , A61K51/12 , A61P35/00
CPC分类号: A61K51/1203 , A61K33/242 , A61K35/28 , A61K41/0052 , A61K47/6901 , A61K49/0065 , A61P35/00
摘要: The present invention refers to cells from a subpopulation of progenitors of endothelial cells loaded with gold nanoparticles sensitive to excitation with infrared radiation with consequent release of thermal energy, to a composition having a plurality of these cells and to their use in the diagnosis and treatment of solid tumours thanks to the selective localization of the composition in the tumour mass, which can be thus identified easily for diagnostic purposes by marking the cells with appropriate marking agents, or treated by stimulation with pulsed laser beam up to the complete cauterization of the tumour mass for a targeted and highly effective therapeutic action.
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公开(公告)号:US20240101623A1
公开(公告)日:2024-03-28
申请号:US18275151
申请日:2022-02-15
发明人: Vania Broccoli , Alessandro Sessa
CPC分类号: C07K14/4703 , C12N9/1007 , C12Y201/01037 , C07K2319/80
摘要: An epigenetic silencer factor (ESF) comprising a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor.
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3.
公开(公告)号:US20230291474A1
公开(公告)日:2023-09-14
申请号:US18040447
申请日:2021-08-03
IPC分类号: H04B10/2581 , H04J14/04
CPC分类号: H04B10/2581 , H04J14/04
摘要: It is disclosed a device for multipole phase division multiplexing and demultiplexing and a spatial division telecommunications system comprising the multiplexing and demultiplexing devices. The multipole phase demultiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a circular-sector transformation of a plurality of multipole phase electromagnetic beams. The multipole phase multiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a combination of |m | circular-sector transformations of a plurality of tilted electromagnetic beams.
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公开(公告)号:US11744901B2
公开(公告)日:2023-09-05
申请号:US16478338
申请日:2018-01-29
IPC分类号: A61K47/69 , A61P35/00 , A61K39/39 , C07K14/52 , C07K14/77 , C07K16/28 , C12N7/00 , A61K39/00
CPC分类号: A61K47/6901 , A61K39/39 , A61P35/00 , C07K14/521 , C07K14/77 , C07K16/2851 , C12N7/00 , A61K2039/55572 , A61K2039/585 , C07K2317/622 , C07K2317/77 , C07K2319/33 , C07K2319/42 , C07K2319/735 , C07K2319/74 , C12N2795/14122 , C12N2795/14132 , C12N2795/14145
摘要: The present invention relates to pharmaceutical compositions containing lipid-bacteriophage conjugates, wherein the bacteriophage:lipid ratio is in the range of 3:1 to 100:1 and wherein the lipid is an immunologically active lipid and the bacteriophage is a filamentous bacteriophage, and uses thereof. Preferably, the bacteriophage is engineered to stimulate an immune response and/or bind to a target cell.
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公开(公告)号:US20230227832A1
公开(公告)日:2023-07-20
申请号:US18002213
申请日:2021-06-17
发明人: Vittorio DE FRANCISCIS , Gerolama CONDORELLI , Silvia CATUOGNO , Carla Lucia ESPOSITO , Cristina QUINTAVALLE , Francesco INGENITO
IPC分类号: C12N15/115 , C12N15/10 , C12Q1/6886
CPC分类号: C12N15/115 , C12N15/1048 , C12Q1/6886 , C12N2310/16
摘要: The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.
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公开(公告)号:US20230167453A1
公开(公告)日:2023-06-01
申请号:US17995343
申请日:2021-04-01
IPC分类号: C12N15/115 , A61P35/00
CPC分类号: C12N15/115 , A61P35/00 , C12N2310/16 , C12N2310/322
摘要: Provided herein are RNA aptamers targeting CD5L. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.
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公开(公告)号:US20230101466A1
公开(公告)日:2023-03-30
申请号:US18062105
申请日:2022-12-06
IPC分类号: A61K31/192 , A23L2/39 , A23L2/52 , A61K31/353 , A61K31/7034 , C12C7/04 , C12C7/20 , C12C12/04 , C12H1/22 , C12C1/18 , C12C5/02 , C12C1/16
摘要: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A. The relative polyphenolic composition obtained according to this method is characterized by the fact that it can be in liquid, powder, dry, and lyophilized form, its use and relative beverage or beer according to the present method not obtained with fermentation methods.
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公开(公告)号:US11566070B2
公开(公告)日:2023-01-31
申请号:US16482455
申请日:2018-02-05
IPC分类号: C12N15/11 , C07K16/28 , C12N15/113 , G01N33/574
摘要: The present invention relates to agents that modulate/regulate the activity of the protein TMEM230 for use in the therapeutic treatment of pathologies in which therapeutic regulation of angiogenesis is advisable or necessary.
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公开(公告)号:US20230020133A1
公开(公告)日:2023-01-19
申请号:US17756734
申请日:2020-12-04
发明人: Jonas ZEUNER , Chiara GREGANTI , Roberto OSELLAME
IPC分类号: F21V8/00
摘要: An optical device for controlling light from an external light source including: at least a first and a second waveguide for guiding a light beam emitted from the external light source; and at least a first beam shaping structure with a first light emitting area for emitting a light beam and a second beam shaping structure with a second light emitting area for emitting a light beam, wherein the first waveguide guides the light beam emitted from the external light source to the first beam shaping structure and the second waveguide guides the light beam emitted from the external light source to the second beam shaping structure; wherein the first and the second beam shaping structure-are each configured such that the uniformity of the radiant density profile of a light beam emitted from the respective light emitting area of the respective beam shaping structure is higher than that of the light beam guided to the respective beam shaping structure by the respective waveguide. Backlight unit including such an optical device; and optical system, in particular holographic display, including such a backlight unit and a spatial light modulator.
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公开(公告)号:US20220380766A1
公开(公告)日:2022-12-01
申请号:US17413550
申请日:2019-12-16
发明人: Gabriel LOPEZ-BERESTEIN , Paola AMERO , Cristian RODRIGUEZ-AGUAYO , Rahul MITRA , Anil K. SOOD , Vittorio DE FRANCISCIS , David VOLK , Lokesh Ganesh L. RAO
IPC分类号: C12N15/115 , A61K31/337 , A61K33/243 , A61P35/00
摘要: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.
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