公开(公告)号：US20210214424A1

公开(公告)日：2021-07-15

申请号：US17054994

申请日：2019-05-16

申请人： CHANG GUNG MEMORIAL HOSPITAL, LINKOU ,  ACADEMIA SINICA

发明人： Alice YU ,  Han-Chung WU ,  John YU

IPC分类号： C07K16/18 ,  A61K47/68 ,  A61P35/00

摘要： The present invention provides monoclonal antibodies or the antigen-binding portion thereof, that bind to a feto-embryonic dedifferentiated antigen, such as Leucine-rich Repeat Neuronal Protein 1 (LRRN1), a surface glycoprotein that is expressed abundantly on the surface of human embryonic stem cells prior to differentiation into embryoid bodies. Also disclosed herein are the uses of the novel LRRN1 antibodies.

公开(公告)号：US20180196053A1

公开(公告)日：2018-07-12

申请号：US15865727

申请日：2018-01-09

申请人： Chang Gung Memorial Hospital, Linkou

发明人： John YU ,  Alice YU

IPC分类号： G01N33/574 ,  C12Q1/6886 ,  C07K16/30

CPC分类号： G01N33/57434 ,  C07K14/4748 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N33/57438 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/705

摘要： Kits for detecting cancer, including an agent for measuring LRRN1 antibody and a label indicating that the reagent for measuring LRRN1 antibody is for detecting cancer are disclosed. Methods for detecting cancer in a subject, including the steps of measuring the level of LRRN1 antibody, wherein a higher LRRN1 antibody level in the subject compare to a control sample, indicates the presence of cancer, are also provided.