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1.发明授权Composition for preventing or treating autoimmune disease, comprising, as active ingredient, PINK1 protein or polynucleotide encoding same 有权用于预防或治疗自身免疫性疾病的组合物，其包含PINK1蛋白或编码其的多核苷酸作为活性成分公开(公告)号：US09585945B2
公开(公告)日：2017-03-07
申请号：US14948095
申请日：2015-11-20
Inventor： Mi-La Cho , Hyang-Suk Rhim , Seon-Yeong Lee , Yeong-Mi Mun , Hye-Jin Son , Eun-Ji Yang , Eun-Kyung Kim
CPC classification number: A61K38/45 , A61K48/005 , C12N9/12 , C12Y207/11001
Abstract: The present invention relates to a composition for preventing or treating an autoimmune disease comprising, as an active ingredient, PINK1 protein or polynucleotide encoding the same. The PINK1 protein according to the present invention inhibits the activity of Th17, promotes the activity of a regulatory T cell (Treg), and increases autophagy in Treg cells, thereby controlling excessive immune responses. Therefore, the PINK1 protein can be effectively used as a pharmaceutical composition or an immunosuppressant, which is capable of preventing or treating an autoimmune disease, such as arthritis, and the like, caused by dysregulation of various kinds of immune responses.
Abstract translation: 本发明涉及用于预防或治疗自身免疫疾病的组合物，其包含作为活性成分的PINK1蛋白或编码该组合物的多核苷酸。 根据本发明的PINK1蛋白抑制Th17的活性，促进调节性T细胞（Treg）的活性，并增加Treg细胞中的自噬，由此控制过度的免疫应答。 因此，可以将PINK1蛋白质有效地用作药物组合物或免疫抑制剂，其能够预防或治疗由各种免疫反应失调引起的自身免疫疾病如关节炎等。
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2.发明申请COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, COMPRISING, AS ACTIVE INGREDIENT, PINK1 PROTEIN OR POLYNUCLEOTIDE ENCODING SAME 有权用于预防或治疗自身免疫疾病的组合物，包含作为活性成分，PINK1蛋白或编码其的多核苷酸公开(公告)号：US20160114007A1
公开(公告)日：2016-04-28
申请号：US14948095
申请日：2015-11-20
Inventor： Mi-La Cho , Hyang-Suk Rhim , Seon-Yeong Lee , Yeong-Mi Mun , Hye-Jin Son , Eun-Ji Yang , Eun-Kyung Kim
IPC: A61K38/45
CPC classification number: A61K38/45 , A61K48/005 , C12N9/12 , C12Y207/11001
Abstract: The present invention relates to a composition for preventing or treating an autoimmune disease comprising, as an active ingredient, PINK1 protein or polynucleotide encoding the same. The PINK1 protein according to the present invention inhibits the activity of Th17, promotes the activity of a regulatory T cell (Treg), and increases autophagy in Treg cells, thereby controlling excessive immune responses. Therefore, the PINK1 protein can be effectively used as a pharmaceutical composition or an immunosuppressant, which is capable of preventing or treating an autoimmune disease, such as arthritis, and the like, caused by dysregulation of various kinds of immune responses.
Abstract translation: 本发明涉及用于预防或治疗自身免疫疾病的组合物，其包含作为活性成分的PINK1蛋白或编码该组合物的多核苷酸。 根据本发明的PINK1蛋白抑制Th17的活性，促进调节性T细胞（Treg）的活性，并增加Treg细胞中的自噬，从而控制过度的免疫应答。 因此，可以将PINK1蛋白质有效地用作药物组合物或免疫抑制剂，其能够预防或治疗由各种免疫反应失调引起的自身免疫疾病如关节炎等。
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