Invention Grant
US09585945B2 Composition for preventing or treating autoimmune disease, comprising, as active ingredient, PINK1 protein or polynucleotide encoding same
有权
用于预防或治疗自身免疫性疾病的组合物，其包含PINK1蛋白或编码其的多核苷酸作为活性成分
- Patent Title: Composition for preventing or treating autoimmune disease, comprising, as active ingredient, PINK1 protein or polynucleotide encoding same
- Patent Title (中): 用于预防或治疗自身免疫性疾病的组合物，其包含PINK1蛋白或编码其的多核苷酸作为活性成分
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Application No.: US14948095Application Date: 2015-11-20
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Publication No.: US09585945B2Publication Date: 2017-03-07
- Inventor: Mi-La Cho , Hyang-Suk Rhim , Seon-Yeong Lee , Yeong-Mi Mun , Hye-Jin Son , Eun-Ji Yang , Eun-Kyung Kim
- Applicant: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
- Applicant Address: KR Seoul
- Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
- Current Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
- Current Assignee Address: KR Seoul
- Agency: JHK Law
- Agent Joseph Hyosuk Kim
- Priority: KR10-2013-0057659 20130522
- Main IPC: C12N9/12
- IPC: C12N9/12 ; A61K48/00 ; A61K38/45
Abstract:
The present invention relates to a composition for preventing or treating an autoimmune disease comprising, as an active ingredient, PINK1 protein or polynucleotide encoding the same. The PINK1 protein according to the present invention inhibits the activity of Th17, promotes the activity of a regulatory T cell (Treg), and increases autophagy in Treg cells, thereby controlling excessive immune responses. Therefore, the PINK1 protein can be effectively used as a pharmaceutical composition or an immunosuppressant, which is capable of preventing or treating an autoimmune disease, such as arthritis, and the like, caused by dysregulation of various kinds of immune responses.
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