公开(公告)号：US09968680B2

公开(公告)日：2018-05-15

申请号：US14551761

申请日：2014-11-24

申请人： CAMURUS AB

发明人： Fredrik Joabsson ,  Margareta Linden ,  Krister Thuresson ,  Fredrik Tiberg

IPC分类号： A61K47/24 ,  A61K47/10 ,  A61K47/14 ,  A61Q11/00 ,  A61K31/4468 ,  A61K38/23 ,  A61K8/92 ,  A61K31/191 ,  A61Q17/04 ,  A61K8/02 ,  A61K8/34 ,  A61K8/37 ,  A61K8/49 ,  A61K8/55 ,  A61K9/00 ,  A61K9/12 ,  A61K9/127 ,  A61K9/70 ,  A61K31/155 ,  A61K31/416 ,  A61K45/06 ,  A61Q19/00 ,  A61K47/44 ,  A61K8/21 ,  A61K31/196 ,  A61K31/198 ,  A61K31/4025 ,  A61K31/5513 ,  A61K47/22

CPC分类号： A61K47/24 ,  A61K8/0295 ,  A61K8/21 ,  A61K8/34 ,  A61K8/37 ,  A61K8/375 ,  A61K8/494 ,  A61K8/553 ,  A61K8/92 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/12 ,  A61K9/1274 ,  A61K9/7015 ,  A61K31/155 ,  A61K31/191 ,  A61K31/196 ,  A61K31/198 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4468 ,  A61K31/5513 ,  A61K38/23 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/44 ,  A61K2800/48 ,  A61K2800/59 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00

摘要： The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

公开(公告)号：US09649382B2

公开(公告)日：2017-05-16

申请号：US14138704

申请日：2013-12-23

申请人： CAMURUS AB

发明人： Fredrik Joabsson ,  Margareta Linden ,  Krister Thuresson ,  Fredrik Tiberg

IPC分类号： A61K8/00 ,  A61K47/24 ,  A61K33/16 ,  A61K31/198 ,  A61K8/02 ,  A61Q19/00 ,  A61K8/37 ,  A61K31/155 ,  A61K31/196 ,  A61K31/355 ,  A61K31/416 ,  A61K31/4468 ,  A61K31/5513 ,  A61K31/573 ,  A61K31/7056 ,  A61K47/10 ,  A61K47/14 ,  A61K9/00 ,  A61K47/22 ,  A61K9/70 ,  A61K8/55 ,  A61K31/568 ,  A61Q17/04

CPC分类号： A61K47/24 ,  A61K8/0216 ,  A61K8/375 ,  A61K8/553 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/7015 ,  A61K31/155 ,  A61K31/196 ,  A61K31/198 ,  A61K31/355 ,  A61K31/416 ,  A61K31/4468 ,  A61K31/5513 ,  A61K31/568 ,  A61K31/573 ,  A61K31/7056 ,  A61K33/16 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K2800/10 ,  A61Q17/04 ,  A61Q19/00

摘要： The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of:a) at least one neutral diacyl lipid and/or at least one tocopherol;b) at least one phospholipid;c) at least one biocompatible, oxygen containing, low viscosity organic solvent;wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.