公开(公告)号：US20240366801A1

公开(公告)日：2024-11-07

申请号：US18683962

申请日：2022-08-16

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Arnaud COMMENT ,  Adam GAUNT ,  Jennifer Sunari LEWIS ,  Irene MARCO-RIUS ,  Tian CHENG

IPC: A61K49/10 ,  A61K49/18

Abstract: In a method for preparing a hyperpolarised sample, for example for a magnetic resonance procedure, a starting solution comprising alpha-ketoglutaric acid and 13C-labelled molecules is frozen to form a frozen solution. The solution is irradiated with ultraviolet and/or visible radiation, to generate free radicals. The frozen solution is then hyperpolarised by applying a magnetic field to the solution while irradiating it with frequency-modulated microwave radiation.

公开(公告)号：US20240369653A1

公开(公告)日：2024-11-07

申请号：US18684000

申请日：2022-08-16

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Arnaud COMMENT ,  Adam GAUNT

IPC: G01R33/28 ,  G01N1/28 ,  G01N1/42 ,  G01N1/44 ,  G01R33/30

Abstract: In a method for preparing a hyperpolarised sample, for example for carrying out a magnetic resonance technique, the sample is formed as a frozen layer (4) of a starting solution on a surface of a thermoconductive sample holder (1,2). The solution comprises molecules for hyperpolarisation, and photo-reactive molecules. Free radicals are induced in the frozen layer by exposing it to radiation. The sample is then hyperpolarised by dynamic nuclear polarization at a dynamic nuclear polarization temperature. After hyperpolarisation, the temperature of the sample is raised to a thermalisation or quenching temperature by thermal conduction of heat through the sample holder, to quench the free radicals. The polarised sample may then be stored for use, retaining its polarisation.