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    Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
    1.
    发明授权
    Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure 有权
    用于在自动化流体转移过程中并入电容式接近感测的方法，系统和装置

    公开(公告)号：US09046507B2

    公开(公告)日：2015-06-02

    申请号：US13192828

    申请日：2011-07-28

    申请人： Byron J. Knight ,  David Opalsky ,  Brian Schroeter

    发明人： Byron J. Knight ,  David Opalsky ,  Brian Schroeter

    IPC分类号： G01F23/26 ,  G01N35/10

    CPC分类号： G01N35/1011 ,  G01F23/263 ,  G01N2035/1013

    摘要： A fluid transfer apparatus includes a fluid transfer probe, a fluid level detection system, and a tip detection system. The fluid level detection system is configured to detect contact by the fluid transfer probe with a fluid surface within a receptacle from a signal based on the capacitance of the fluid transfer probe. The tip detection system is configured to detect the presence or absence of a tip at a distal end of the fluid transfer probe from a signal based on the capacitance of the fluid transfer probe.

    摘要翻译： 液体输送装置包括流体转移探针，液位检测系统和尖端检测系统。 流体液位检测系统配置成基于流体转移探针的电容从信号中检测流体转移探针与容器内的流体表面的接触。 尖端检测系统被配置为基于流体转移探针的电容从信号中检测流体转移探针的远端处的尖端的存在或不存在。

    Method and apparatus for effecting automated movement of a magnet in an instrument for performing a magnetic separation procedure
    2.
    发明授权
    Method and apparatus for effecting automated movement of a magnet in an instrument for performing a magnetic separation procedure 有权
    用于实现用于执行磁分离程序的仪器中的磁体的自动移动的方法和装置

    公开(公告)号：US09011771B2

    公开(公告)日：2015-04-21

    申请号：US12781390

    申请日：2010-05-17

    申请人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

    发明人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

    IPC分类号： G01N35/04 ,  G01N35/10 ,  B03C1/28 ,  G01N35/00 ,  B03C1/033

    CPC分类号： B01L3/52 ,  B01L3/561 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/12 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/14 ,  B03C1/28 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B25J11/00 ,  B65B3/04 ,  C12N15/1013 ,  G01N35/0098 ,  Y10T29/49815

    摘要： Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.

    摘要翻译： 提供了方法，系统和装置，用于自动分离来自样品的其它组分的选定的分析物，其中磁性响应性固体支持物被结合。 用于执行自动磁分离程序的装置包括用于在相对于插座装置的操作位置和非操作位置之间实现磁体的线性移动的机构。 在将容器移动到用于执行磁性分离的装置之前可以临时存储插座装置的容器保持站包括用于向保持在其中的插座装置施加磁场的磁体，从而至少吸取磁响应的质子 在插座装置移动到磁选分离台之前，固体支撑体不能悬挂。 自动插座传送机构使插座装置在用于执行磁分离的装置和插座保持台之间移动。

    Method and apparatus for effecting transfer of reaction receptacles in an instrument for multi-step analytical procedures
    3.
    发明授权
    Method and apparatus for effecting transfer of reaction receptacles in an instrument for multi-step analytical procedures 有权
    用于在仪器中进行多步分析程序的反应容器的转移的方法和装置

    公开(公告)号：US08731712B2

    公开(公告)日：2014-05-20

    申请号：US13320746

    申请日：2010-05-17

    申请人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky ,  Jason Rhubottom ,  Olaf Hörger ,  Harald Thahedl ,  Heiko Sayer ,  Stefan Habrich

    发明人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky ,  Jason Rhubottom ,  Olaf Hörger ,  Harald Thahedl ,  Heiko Sayer ,  Stefan Habrich

    IPC分类号： G06F7/00

    CPC分类号： B65G47/901 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/0413 ,  G01N2035/0422 ,  G01N2035/0484

    摘要： Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.

    摘要翻译： 用于在仪器的模块之间进行反应容器的传送以用于执行多步骤分析程序并用于调整这些模块的位置变化的系统包括支撑在轨道上的插座载体，载体在载体上在不同模块之间平移， 跟踪。 托架包括支撑在插座托架上的插座分配头。 分配头包括容纳移动机构，其适于将容器移入和移出分配头并进出模块。 滑架与轨道接合并适应轨道的翻译。 驱动系统影响滑架的动力翻转，分配头的动力升降和旋转，以及插座进出分配头的动力运动。 传送位置定位系统自动确定插座托架相对于每个模块的插座传送位置。

    CONTAMINATION CONTROL FOR LIQUID HANDLING
    4.
    发明申请
    CONTAMINATION CONTROL FOR LIQUID HANDLING 有权
    液体处理污染控制

    公开(公告)号：US20120261469A1

    公开(公告)日：2012-10-18

    申请号：US13320749

    申请日：2010-05-17

    申请人： Craig B. Clark ,  John M. Gilker ,  Norbert D. Hagen ,  Tom R. Horn ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Waldemar Lukhaub ,  Olaf Hörger

    发明人： Craig B. Clark ,  John M. Gilker ,  Norbert D. Hagen ,  Tom R. Horn ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Waldemar Lukhaub ,  Olaf Hörger

    IPC分类号： G06Q90/00 ,  B01L9/06

    CPC分类号： G06Q10/087 ,  B01L9/06 ,  B01L2200/023 ,  B01L2200/06 ,  B01L2200/141 ,  B01L2300/021 ,  G01N35/1004

    摘要： A structure (10) for holding sample-containing receptacles includes a cover (40) with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element (44) adjacent each opening (42) engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.

    摘要翻译： 用于保持含有样品的容器的结构（10）包括其中形成有孔的盖（40），通过所述盖（40）可以用诸如机器人移液器的物质转移机构接近所述容器。 当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。 邻近每个开口（42）的粘性排除元件（44）与粘性材料串接合，并且当机构相对于去除元件以规定的路径移动时，将串从机构中移出。 被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征 口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

    METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES
    5.
    发明申请
    METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES 有权
    用于多步骤分析程序的仪器中反应接头的转移的方法和装置

    公开(公告)号：US20120128451A1

    公开(公告)日：2012-05-24

    申请号：US13320746

    申请日：2010-05-17

    申请人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Olaf Hörger ,  Heiko Sayer ,  Harald Thahedl ,  Stefan Habrich

    发明人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Olaf Hörger ,  Heiko Sayer ,  Harald Thahedl ,  Stefan Habrich

    IPC分类号： B65G47/00

    CPC分类号： B65G47/901 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/0413 ,  G01N2035/0422 ,  G01N2035/0484

    摘要： Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.

    摘要翻译： 用于在仪器的模块之间进行反应容器的传送以用于执行多步骤分析程序并用于调整这些模块的位置变化的系统包括支撑在轨道上的插座载体，载体在载体上在不同模块之间平移， 跟踪。 托架包括支撑在插座托架上的插座分配头。 分配头包括容纳移动机构，其适于将容器移入和移出分配头并进出模块。 滑架与轨道接合并适应轨道的翻译。 驱动系统影响滑架的动力翻转，分配头的动力升降和旋转，以及插座进出分配头的动力运动。 传送位置定位系统自动确定插座托架相对于每个模块的插座传送位置。

    Contamination control for liquid handling
    6.
    发明授权
    Contamination control for liquid handling 有权
    液体处理的污染控制

    公开(公告)号：US08939364B2

    公开(公告)日：2015-01-27

    申请号：US13320749

    申请日：2010-05-17

    申请人： Craig B. Clark ,  John M. Gilker ,  Norbert D. Hagen ,  Tom R. Horn ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Waldemar Lukhaub ,  Olaf Hörger

    发明人： Craig B. Clark ,  John M. Gilker ,  Norbert D. Hagen ,  Tom R. Horn ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Waldemar Lukhaub ,  Olaf Hörger

    IPC分类号： G06K19/00 ,  G06Q10/08 ,  B01L9/06 ,  G01N35/10

    CPC分类号： G06Q10/087 ,  B01L9/06 ,  B01L2200/023 ,  B01L2200/06 ,  B01L2200/141 ,  B01L2300/021 ,  G01N35/1004

    摘要： A structure (10) for holding sample-containing receptacles includes a cover (40) with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element (44) adjacent each opening (42) engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.

    摘要翻译： 用于保持含有样品的容器的结构（10）包括其中形成有孔的盖（40），通过所述盖（40）可以用诸如机器人移液器的物质转移机构接近所述容器。 当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。 邻近每个开口（42）的粘性排除元件（44）与粘性材料串接合，并且当机构相对于去除元件以规定的路径移动时，将串从机构中移出。 被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征 口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

    Method and Apparatus for Effecting Automated Movement of a Magnet in an Instrument for Performing a Magnetic Separation Procedure
    7.
    发明申请
    Method and Apparatus for Effecting Automated Movement of a Magnet in an Instrument for Performing a Magnetic Separation Procedure 有权
    用于实现磁选机的磁铁自动运动的方法和装置

    公开(公告)号：US20100288395A1

    公开(公告)日：2010-11-18

    申请号：US12781390

    申请日：2010-05-17

    申请人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

    发明人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

    IPC分类号： B65B1/04

    CPC分类号： B01L3/52 ,  B01L3/561 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/12 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/14 ,  B03C1/28 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B25J11/00 ,  B65B3/04 ,  C12N15/1013 ,  G01N35/0098 ,  Y10T29/49815

    摘要： Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.

    摘要翻译： 提供了方法，系统和装置，用于自动分离来自样品的其它组分的选定的分析物，其中磁性响应性固体支持物被结合。 用于执行自动磁分离程序的装置包括用于在相对于插座装置的操作位置和非操作位置之间实现磁体的线性移动的机构。 在将容器移动到用于执行磁性分离的装置之前可以临时存储插座装置的容器保持站包括用于向保持在其中的插座装置施加磁场的磁体，从而至少吸取磁响应的质子 在插座装置移动到磁选分离台之前，固体支撑体不能悬挂。 自动插座传送机构使插座装置在用于执行磁分离的装置和插座保持台之间移动。

    Sample tube holder
    9.
    发明授权
    Sample tube holder 有权
    样品管架

    公开(公告)号：US07910067B2

    公开(公告)日：2011-03-22

    申请号：US11379205

    申请日：2006-04-18

    申请人： Byron J. Knight ,  Mark A. Talmer ,  Arthur G. Sandoval ,  Robert A. Howard ,  Rommel M. Hipolito ,  Robert F. Scalese

    发明人： Byron J. Knight ,  Mark A. Talmer ,  Arthur G. Sandoval ,  Robert A. Howard ,  Rommel M. Hipolito ,  Robert F. Scalese

    IPC分类号： B01L9/06

    CPC分类号： G01N35/025 ,  B01L9/06 ,  B01L2200/025 ,  B01L2300/021 ,  G01N2035/0446 ,  G01N2035/0451 ,  G01N2035/0465 ,  Y10S435/809

    摘要： A sample tube holder having sample tube compartments with sets of spaced finger springs provided therein for maintaining sample tubes in substantially upright orientations. A guide structure having a series of openings is used to direct sample tubes into the sample tube compartments and to restrict lateral movement of sample tubes held thereby. A retainer is releasably engaged by the guide structure and has openings sized to provide access to sample tubes held by the sample tube compartments but which restrict vertical movement of the sample tubes. Tabs at a base of the sample tube holder and hold-downs fixed to a stationary structure adjacent a conveyor cooperate to restrict vertical movement of the sample tube holder during automated sampling procedures.

    摘要翻译： 样品管架，其具有样品管隔室，其中设置有间隔的指状弹簧，用于将样品管保持在基本上直立的取向。 具有一系列开口的引导结构用于将样品管引导到样品管隔室中并且限制由此保持的样品管的横向移动。 保持器由引导结构可释放地接合并且具有尺寸设置成提供对由样品管隔室保持的样品管进入但限制样品管的垂直运动的开口。 在样品管支架的基部处的突片和固定到邻近输送机的固定结构的压紧器协调，以限制在自动采样过程中样品管支架的垂直运动。