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    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    1.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 审中-公开

    公开(公告)号：US20200079835A1

    公开(公告)日：2020-03-12

    申请号：US16516225

    申请日：2019-07-18

    申请人： BRISTOL-MYERS SQUIBB COMPANY

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705 ,  C07K16/28

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    2.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20130144042A1

    公开(公告)日：2013-06-06

    申请号：US13711855

    申请日：2012-12-12

    申请人： Bristol-Myers Squibb Company

    发明人： Glen Eugene Mikesell ,  Henry Shen ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach

    IPC分类号： C07K19/00

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  A61K38/1774 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/2827 ,  C07K19/00 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/10 ,  C07K2319/30 ,  C07K2319/40 ,  G01N33/5005 ,  Y02A50/396

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    Polynucleotides encoding BSL2v2c2
    3.
    发明授权
    Polynucleotides encoding BSL2v2c2 有权
    编码BSL2v2c2的多核苷酸

    公开(公告)号：US09409970B2

    公开(公告)日：2016-08-09

    申请号：US14178360

    申请日：2014-02-12

    申请人： BRISTOL-MYERS SQUIBB COMPANY

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K16/28 ,  A61K47/48 ,  A61K38/00

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。