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公开(公告)号：US07910715B2
公开(公告)日：2011-03-22
申请号：US11937888
申请日：2007-11-09
CPC分类号： C12N15/77 , A23K10/12 , A23K20/147 , C07K14/34 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
摘要翻译： 本发明涉及编码OxyR转录调节子变体的棒状细菌的oxyR基因的突变体和等位基因，以及使用包含这些等位基因的细菌产生氨基酸的方法。
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公开(公告)号：US07754446B2
公开(公告)日：2010-07-13
申请号：US11873073
申请日：2007-10-16
IPC分类号： C12P1/00
CPC分类号： C12P13/08 , A23L33/135 , A23L33/175 , C12N9/1235 , C12P13/04
摘要： An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
摘要翻译： 棒状细菌的分离突变体，其包含编码具有GTP-焦磷酸激酶活性的多肽的基因，其中所述多肽包含氨基酸序列，其中除了L-脯氨酸以外的蛋白原氨基酸之一存在于位置38或相应的 或相当的地位。 此外，描述了编码具有GTP焦磷酸激酶酶活性的多肽的分离的多核苷酸，包含分离的多核苷酸的载体，包含载体的重组微生物和制备重组棒状杆菌型细菌的方法。 还描述了过表达GTP焦磷酸激酶的方法，制备L-氨基酸的方法，包含L-赖氨酸的L-赖氨酸和包含L-色氨酸的饲料。
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公开(公告)号：US20080261269A1
公开(公告)日：2008-10-23
申请号：US11937888
申请日：2007-11-09
CPC分类号： C12N15/77 , A23K10/12 , A23K20/147 , C07K14/34 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
摘要翻译： 本发明涉及编码OxyR转录调节子变体的棒状细菌的oxyR基因的突变体和等位基因，以及使用包含这些等位基因的细菌产生氨基酸的方法。
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公开(公告)号：US08592187B2
公开(公告)日：2013-11-26
申请号：US13027732
申请日：2011-02-15
CPC分类号： C12N15/77 , A23K10/12 , A23K20/147 , C07K14/34 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
摘要翻译： 本发明涉及编码OxyR转录调节子变体的棒状细菌的oxyR基因的突变体和等位基因，以及使用包含这些等位基因的细菌产生氨基酸的方法。
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5.发明申请公开(公告)号：US20100255544A1
公开(公告)日：2010-10-07
申请号：US12553647
申请日：2009-09-03
IPC分类号： C12P19/38 , C12P1/00 , C12P19/30 , C12P13/04 , C12P13/24 , C12P13/22 , C12P13/20 , C12P13/14 , C12P13/12 , C12P13/08 , C12P13/06 , C12N15/74 , C12N1/21 , C12N15/63
CPC分类号： C12P13/08
摘要： The invention relates to coryneform bacteria which, instead of the singular copy of an open reading frame (ORF), gene or allele naturally present at the particular desired site (locus), have at least two copies of the open reading frame (ORF), gene or allele in question, preferably in tandem arrangement, and optionally at least a third copy of the open reading frame (ORF), gene or allele in question at a further gene site, and processes for the preparation of chemical compounds by fermentation of these bacteria.
摘要翻译： 本发明涉及棒状细菌，代替开放阅读框（ORF）的单一拷贝，天然存在于特定所需位点（基因座）的基因或等位基因具有至少两个开放阅读框（ORF）的拷贝， 基因或等位基因，优选串联排列，以及任选地在另一基因位点处的开放阅读框（ORF），所述基因或等位基因的至少第三拷贝，以及通过这些发酵制备化合物的方法 菌。
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公开(公告)号：US20080274265A1
公开(公告)日：2008-11-06
申请号：US11923942
申请日：2007-10-25
CPC分类号： C12P13/08 , A23K10/12 , A23K20/142 , C12N9/88 , C12P13/227
摘要： An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.
摘要翻译： 包含基因的棒状细菌的分离突变体编码具有2-甲基柠檬酸脱水酶活性的多肽，其中多肽包含氨基酸序列，其中除了L-脯氨酸之外的一种蛋白原氨基酸存在于位置272或相应或可比较的位置 。 此外，描述了编码具有2-甲基柠檬酸脱水酶酶活性的多肽的分离的多核苷酸，其在氨基酸序列的位置272或相应的或可比较的位置包含L-脯氨酸以外的蛋白质氨基酸。 一种重组棒状杆菌型细菌和L-氨基酸的制备方法。 还描述了重组微生物，含L-赖氨酸的饲料添加剂和含L-色氨酸的饲料添加剂。
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公开(公告)号：US20110171695A1
公开(公告)日：2011-07-14
申请号：US13009051
申请日：2011-01-19
CPC分类号： C12P13/08 , A23K10/12 , A23K20/142 , C12N9/88 , C12P13/227
摘要： An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.
摘要翻译： 包含基因的棒状细菌的分离突变体编码具有2-甲基柠檬酸脱水酶活性的多肽，其中多肽包含氨基酸序列，其中除了L-脯氨酸之外的一种蛋白原氨基酸存在于位置272或相应或可比较的位置 。 此外，描述了编码具有2-甲基柠檬酸脱水酶酶活性的多肽的分离的多核苷酸，其在氨基酸序列的位置272或相应的或可比较的位置包含L-脯氨酸以外的蛋白质氨基酸。 一种重组棒状杆菌型细菌和L-氨基酸的制备方法。 还描述了重组微生物，含L-赖氨酸的饲料添加剂和含L-色氨酸的饲料添加剂。
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公开(公告)号：US20070111291A1
公开(公告)日：2007-05-17
申请号：US11612208
申请日：2006-12-18
IPC分类号： C12P13/24 , C12P13/22 , C12P13/04 , C12P13/20 , C12P13/14 , C12P13/08 , C12N15/74 , C12N1/21
摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
摘要翻译： 本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌， 在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物 通过这些细菌的发酵。
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公开(公告)号：US07160711B2
公开(公告)日：2007-01-09
申请号：US10358405
申请日：2003-02-05
摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
摘要翻译： 本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌， 在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物 通过这些细菌的发酵。
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公开(公告)号：US20130142937A1
公开(公告)日：2013-06-06
申请号：US13027732
申请日：2011-02-15
IPC分类号： C12N15/77
CPC分类号： C12N15/77 , A23K10/12 , A23K20/147 , C07K14/34 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
摘要翻译： 本发明涉及编码OxyR转录调节子变体的棒状细菌的oxyR基因的突变体和等位基因，以及使用包含这些等位基因的细菌产生氨基酸的方法。
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