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公开(公告)号：US08470297B1
公开(公告)日：2013-06-25
申请号：US12879359
申请日：2010-09-10
申请人： Brian DerHua Lu , Siu-Long Yao , Cynthia Seidel-Dugan , Yan Wang
发明人： Brian DerHua Lu , Siu-Long Yao , Cynthia Seidel-Dugan , Yan Wang
CPC分类号： A61K51/0491
摘要： This invention relates to methods for evaluating the efficacy of an IGF1R inhibitor, such as an anti-IGF1R antibody, for the treatment of an Ewing's sarcoma tumor by determining the level of tumoral glucose metabolism. Tumoral glucose metabolism is determining at an early point in the treatment regimen by any of several methods known in the art including FDG-PET/CT scan.
摘要翻译： 本发明涉及通过测定肿瘤葡萄糖代谢水平来评估IGF1R抑制剂如抗IGF1R抗体在治疗尤文氏肉瘤肿瘤中的功效的方法。 肿瘤葡萄糖代谢通过本领域已知的几种方法中的任一种包括FDG-PET / CT扫描在治疗方案的早期确定。
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公开(公告)号：US20110262525A1
公开(公告)日：2011-10-27
申请号：US12518409
申请日：2007-12-11
申请人： Yan Wang , Chen Zong , Cynthia Seidel-Dugan , Yaolin Wang , Siu-Long Yao , Brian Der-Hua Lu , Mohamad H. Ladha
发明人： Yan Wang , Chen Zong , Cynthia Seidel-Dugan , Yaolin Wang , Siu-Long Yao , Brian Der-Hua Lu , Mohamad H. Ladha
IPC分类号： A61K39/395 , A61K31/4985 , A61K31/704 , A61K9/127 , A61K31/7072 , A61K31/56 , A61K31/501 , A61K38/46 , A61K39/07 , A61K38/00 , A61K38/18 , A61K38/21 , A61K38/20 , A61P35/00 , A61P35/02 , A61K31/519
CPC分类号： A61K31/00 , A61K31/519 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
摘要翻译： 本发明涉及可用于治疗各种癌症的组合物和方法。 治疗组合及其使用方法也在本申请中被覆盖。
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3.发明申请公开(公告)号：US20110129456A1
公开(公告)日：2011-06-02
申请号：US12991228
申请日：2009-05-04
申请人： Yaolin Wang , Yan Wang , Brian Der-Hua Lu , Ming Liu , Cynthia Seidel-Dugan , Siu-Long Yao
发明人： Yaolin Wang , Yan Wang , Brian Der-Hua Lu , Ming Liu , Cynthia Seidel-Dugan , Siu-Long Yao
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/675 , A61K39/39533 , A61K2039/545 , C07K2317/56 , C07K2317/565 , A61K2300/00
摘要： The present invention relates to the sequential administration of a cytotoxic agent followed by an IGF1R antagonist (e.g., an antibody) for the treatment of hyperproliferative disorders including cancer.
摘要翻译： 本发明涉及依次施用细胞毒剂，随后是IGF1R拮抗剂（例如抗体），用于治疗包括癌症在内的过度增殖性疾病。
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公开(公告)号：US20110091524A1
公开(公告)日：2011-04-21
申请号：US12808270
申请日：2008-12-17
申请人： Yan Wang , Yaolin Wang , Diene Levitan , Cynthia Seidel-Dugan , Ming Liu , Wei Ding
发明人： Yan Wang , Yaolin Wang , Diene Levitan , Cynthia Seidel-Dugan , Ming Liu , Wei Ding
IPC分类号： A61K39/395 , C12Q1/68 , A61K38/20 , A61K38/21 , A61K9/127 , A61P35/00 , A61P35/02 , G06Q90/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06Q99/00
摘要： The present invention provides, for example, methods for conveniently determining if a cancerous condition in a subject will be responsive to an IGF1R inhibitor. The invention includes patient selection methods and methods of treatment.
摘要翻译： 本发明提供了例如方便地确定受试者的癌症状况是否对IGF1R抑制剂有反应的方法。 本发明包括患者选择方法和治疗方法。
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公开(公告)号：US20110104256A1
公开(公告)日：2011-05-05
申请号：US12934458
申请日：2009-03-23
申请人： Yaolin Wang , Yan Wang , Ming Liu , Walter Robert Bishop , Cynthia Seidel-Dugan
发明人： Yaolin Wang , Yan Wang , Ming Liu , Walter Robert Bishop , Cynthia Seidel-Dugan
CPC分类号： A61K31/505 , A61K31/436 , A61K31/513 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , A61K2300/00
摘要： The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and 5-fluorouracil.
摘要翻译： 本发明提供了例如与舒尼替尼或甲酰四氢叶酸和5-氟尿嘧啶的组合相结合的抗IGF1R抗体治疗或预防结肠直肠癌的方法。
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公开(公告)号：US11952603B2
公开(公告)日：2024-04-09
申请号：US16108930
申请日：2018-08-22
申请人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
发明人： Kenneth S. Manning , Yan Wang , Dustin Nielsen , Ryan Ruf , Colin Crowley , Jon Restivo , Dana Spangenberg , Karla Anhalt , Mark Romich , Anisha Akula , Carmen Fritz
CPC分类号： C12N9/94 , A61K9/00 , A61K31/327 , A61K35/39 , A61K38/46 , C12N7/00 , C12N2750/10063 , C12N2750/14363 , C12N2770/32263 , A61K35/39 , A61K2300/00 , A61K38/46 , A61K2300/00 , A61K31/327 , A61K2300/00
摘要： A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.
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公开(公告)号：US11579086B2
公开(公告)日：2023-02-14
申请号：US17496262
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.
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公开(公告)号：US20220026363A1
公开(公告)日：2022-01-27
申请号：US17496285
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.
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公开(公告)号：US20220026362A1
公开(公告)日：2022-01-27
申请号：US17496262
申请日：2021-10-07
申请人： Yan Wang , Cory McCluskey
发明人： Yan Wang , Cory McCluskey
摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.
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