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    Gene disruptions, compositions and methods relating thereto
    1.
    发明授权
    Gene disruptions, compositions and methods relating thereto 失效
    基因破坏，组合物和方法

    公开(公告)号：US08207396B2

    公开(公告)日：2012-06-26

    申请号：US13031009

    申请日：2011-02-18

    申请人： Bobby Joe Payne ,  Mary Jean Sparks ,  Wen Xiong

    发明人： Bobby Joe Payne ,  Mary Jean Sparks ,  Wen Xiong

    IPC分类号： G01N33/00

    CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

    摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

    摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

    Reducing idle time due to acknowledgement packet delay
    5.
    发明授权
    Reducing idle time due to acknowledgement packet delay 有权
    由于确认包延迟而减少空闲时间

    公开(公告)号：US08266317B2

    公开(公告)日：2012-09-11

    申请号：US12131167

    申请日：2008-06-02

    申请人： James R. Gallagher ,  Binh K. Hua ,  Hong L. Hua ,  Wen Xiong

    发明人： James R. Gallagher ,  Binh K. Hua ,  Hong L. Hua ,  Wen Xiong

    IPC分类号： G06F15/16

    CPC分类号： H04L47/10 ,  H04L47/193 ,  H04L47/27 ,  H04L47/33

    摘要： Mechanisms for reducing the idle time of a computing device due to delays in transmitting/receiving acknowledgement packets are provided. A first data amount corresponding to a window size for a communication connection is determined. A second data amount, in excess of the first data amount, which may be transmitted with the first data amount, is calculated. The first and second data amounts are then transmitted from the sender to the receiver. The first data amount is provided to the receiver in a receive buffer of the receiver. The second data amount is maintained in a switch port buffer of a switch port without being provided to the receive buffer. The second data amount is transmitted from the switch port buffer to the receive buffer in response to the switch port detecting an acknowledgement packet from the receiver.

    摘要翻译： 提供了由于发送/接收确认分组中的延迟而减少计算设备的空闲时间的机制。 确定对应于通信连接的窗口大小的第一数据量。 计算超过可以以第一数据量发送的第一数据量的第二数据量。 然后，第一和第二数据量从发送器发送到接收器。 在接收器的接收缓冲器中将第一数据量提供给接收器。 第二数据量保持在交换机端口的交换机端口缓冲器中，而不被提供给接收缓冲器。 响应于交换端口检测到来自接收机的确认分组，第二数据量从交换机端口缓冲器发送到接收缓冲器。

    Method to improve system DMA mapping while substantially reducing memory fragmentation
    6.
    发明授权
    Method to improve system DMA mapping while substantially reducing memory fragmentation 失效
    改进系统DMA映射同时显着减少内存碎片的方法

    公开(公告)号：US07739422B2

    公开(公告)日：2010-06-15

    申请号：US11385926

    申请日：2006-03-21

    申请人： Binh Hua ,  Hong L. Hua ,  Dirk Michel ,  Wen Xiong

    发明人： Binh Hua ,  Hong L. Hua ,  Dirk Michel ,  Wen Xiong

    IPC分类号： G06F13/28

    CPC分类号： G06F13/28

    摘要： A method, system and computer program product for eliminating the latency in searching for contiguous memory space by an IO DMA request of a device driver. Three new application programming interfaces (APIs) are provided within the operating system (OS) code that allows the device driver(s) to (1) pre-request and pre-allocate the IO DMA address range from the OS during the IPL and maintain control of the address, (2) map a system (virtual/physical) address range to a specific pre-allocated IO DMA address range, and (3) free the pre-allocated IO DMA address space back to the kernel when the space is no longer required. Utilizing these APIs enables advanced IO DMA address mapping techniques maintained by the device drivers, and the assigned/allocated IO DMA address space is no longer fragmented, and the latency of completing the IO DMA mapping is substantially reduced/eliminated.

    摘要翻译： 一种方法，系统和计算机程序产品，用于消除通过设备驱动程序的IO DMA请求搜索连续存储器空间的延迟。 在操作系统（OS）代码中提供了三个新的应用编程接口（API），允许设备驱动程序（1）在IPL期间从OS预先请求并预分配IO DMA地址范围并维护 控制地址，（2）将系统（虚拟/物理）地址范围映射到特定的预先分配的IO DMA地址范围，以及（3）当空间为空时将预分配的IO DMA地址空间释放回内核 不再需要。 利用这些API可以实现由设备驱动程序维护的高级IO DMA地址映射技术，并且分配/分配的IO DMA地址空间不再分段，并且完全减少/消除了完成IO DMA映射的延迟。

    Method for Changing Ethernet MTU Size on Demand with No Data Loss
    7.
    发明申请
    Method for Changing Ethernet MTU Size on Demand with No Data Loss 失效
    根据需求更改以太网MTU大小的方法，无数据丢失

    公开(公告)号：US20120203878A1

    公开(公告)日：2012-08-09

    申请号：US13449799

    申请日：2012-04-18

    申请人： Binh Hua ,  Hong L. Hua ,  Wen Xiong

    发明人： Binh Hua ,  Hong L. Hua ,  Wen Xiong

    IPC分类号： G06F15/177

    CPC分类号： H04L69/324 ,  H04L69/32

    摘要： A method and system for substantially avoiding loss of data and enabling continuing connection to the application during an MTU size changing operation in an active network computing device. Logic is added to the device driver, which logic provides several enhancements to the MTU size changing operation/process. Among these enhancements are: (1) logic for temporarily pausing the data coming in from the linked partner while changing the MTU size; (2) logic for returning a “device busy” status to higher-protocol transmit requests during the MTU size changing process. This second logic prevents the application from issuing new requests until the busy signal is removed; and (3) logic for enabling resumption of both flows when the MTU size change is completed. With this new logic, the device driver/adapter does not have any transmit and receive packets to process for a short period of time, while the MTU size change is ongoing.

    摘要翻译： 一种用于在活动网络计算设备中在MTU大小改变操作期间基本上避免数据丢失并使得能够持续连接到应用的方法和系统。 逻辑被添加到设备驱动程序，该逻辑提供了对MTU大小改变操作/过程的几个增强。 这些增强功能包括：（1）在改变MTU大小的同时临时暂停从链接伙伴进来的数据的逻辑; （2）在MTU大小改变过程中将“设备忙”状态返回到更高协议传输请求的逻辑。 该第二逻辑防止应用程序发出新的请求，直到忙信号被移除; 和（3）当MTU大小改变完成时能够恢复两个流的逻辑。 使用这种新的逻辑，设备驱动程序/适配器没有任何发送和接收数据包在短时间内处理，而MTU大小更改正在进行。

    Method for changing ethernet MTU size on demand with no data loss
    8.
    发明申请
    Method for changing ethernet MTU size on demand with no data loss 失效
    根据需要更改以太网MTU大小的方法，无数据丢失

    公开(公告)号：US20070230344A1

    公开(公告)日：2007-10-04

    申请号：US11390787

    申请日：2006-03-28

    申请人： Binh Hua ,  Hong Hua ,  Wen Xiong

    发明人： Binh Hua ,  Hong Hua ,  Wen Xiong

    IPC分类号： H04L12/26

    CPC分类号： H04L69/324 ,  H04L69/32

    摘要： A method and system for substantially avoiding loss of data and enabling continuing connection to the application during an MTU size changing operation in an active network computing device. Logic is added to the device driver, which logic provides several enhancements to the MTU size changing operation/process. Among these enhancements are: (1) logic for temporarily pausing the data coming in from the linked partner while changing the MTU size; (2) logic for returning a “device busy” status to higher-protocol transmit requests during the MTU size changing process. This second logic prevents the application from issuing new requests until the busy signal is removed; and (3) logic for enabling resumption of both flows when the MTU size change is completed. With this new logic, the device driver/adapter does not have any transmit and receive packets to process for a short period of time, while the MTU size change is ongoing.

    摘要翻译： 一种用于在活动网络计算设备中在MTU大小改变操作期间基本上避免数据丢失并使得能够持续连接到应用的方法和系统。 逻辑被添加到设备驱动程序，该逻辑提供了对MTU大小改变操作/过程的几个增强。 这些增强功能包括：（1）在改变MTU大小的同时临时暂停从链接伙伴进来的数据的逻辑; （2）在MTU大小改变过程中将“设备忙”状态返回到更高协议传输请求的逻辑。 该第二逻辑防止应用程序发出新的请求，直到忙信号被移除; 和（3）当MTU大小改变完成时能够恢复两个流的逻辑。 使用这种新的逻辑，设备驱动程序/适配器没有任何发送和接收数据包在短时间内处理，而MTU大小更改正在进行。

    Changing Ethernet MTU size on demand with no data loss
    9.
    发明授权
    Changing Ethernet MTU size on demand with no data loss 失效
    根据需要更改以太网MTU大小，无数据丢失

    公开(公告)号：US08214535B2

    公开(公告)日：2012-07-03

    申请号：US11390787

    申请日：2006-03-28

    申请人： Binh Hua ,  Hong L. Hua ,  Wen Xiong

    发明人： Binh Hua ,  Hong L. Hua ,  Wen Xiong

    IPC分类号： G06F13/00

    CPC分类号： H04L69/324 ,  H04L69/32

    摘要： A method and system for substantially avoiding loss of data and enabling continuing connection to the application during an MTU size changing operation in an active network computing device. Logic is added to the device driver, which logic provides several enhancements to the MTU size changing operation/process. Among these enhancements are: (1) logic for temporarily pausing the data coming in from the linked partner while changing the MTU size; (2) logic for returning a “device busy” status to higher-protocol transmit requests during the MTU size changing process. This second logic prevents the application from issuing new requests until the busy signal is removed; and (3) logic for enabling resumption of both flows when the MTU size change is completed. With this new logic, the device driver/adapter does not have any transmit and receive packets to process for a short period of time, while the MTU size change is ongoing.

    摘要翻译： 一种用于在活动网络计算设备中在MTU大小改变操作期间基本上避免数据丢失并使得能够持续连接到应用的方法和系统。 逻辑被添加到设备驱动程序，该逻辑提供了对MTU大小改变操作/过程的几个增强。 这些增强功能包括：（1）在改变MTU大小的同时临时暂停从链接伙伴进来的数据的逻辑; （2）在MTU大小改变过程中将“设备忙”状态返回到更高协议传输请求的逻辑。 该第二逻辑防止应用程序发出新的请求，直到忙信号被移除; 和（3）当MTU大小改变完成时能够恢复两个流的逻辑。 使用这种新的逻辑，设备驱动程序/适配器没有任何发送和接收数据包在短时间内处理，而MTU大小更改正在进行。

    REDUCING IDLE TIME DUE TO ACKNOWLEDGEMENT PACKET DELAY
    10.
    发明申请
    REDUCING IDLE TIME DUE TO ACKNOWLEDGEMENT PACKET DELAY 有权
    由于确认包延迟而减少空闲时间

    公开(公告)号：US20090300211A1

    公开(公告)日：2009-12-03

    申请号：US12131167

    申请日：2008-06-02

    申请人： James R. Gallagher ,  Binh K. Hua ,  Hong L. Hua ,  Wen Xiong

    发明人： James R. Gallagher ,  Binh K. Hua ,  Hong L. Hua ,  Wen Xiong

    IPC分类号： G06F15/16

    CPC分类号： H04L47/10 ,  H04L47/193 ,  H04L47/27 ,  H04L47/33

    摘要： Mechanisms for reducing the idle time of a computing device due to delays in transmitting/receiving acknowledgement packets are provided. A first data amount corresponding to a window size for a communication connection is determined. A second data amount, in excess of the first data amount, which may be transmitted with the first data amount, is calculated. The first and second data amounts are then transmitted from the sender to the receiver. The first data amount is provided to the receiver in a receive buffer of the receiver. The second data amount is maintained in a switch port buffer of a switch port without being provided to the receive buffer. The second data amount is transmitted from the switch port buffer to the receive buffer in response to the switch port detecting an acknowledgement packet from the receiver.

    摘要翻译： 提供了由于发送/接收确认分组中的延迟而减少计算设备的空闲时间的机制。 确定对应于通信连接的窗口大小的第一数据量。 计算超过可以以第一数据量发送的第一数据量的第二数据量。 然后，第一和第二数据量从发送器发送到接收器。 在接收器的接收缓冲器中将第一数据量提供给接收器。 第二数据量保持在交换机端口的交换机端口缓冲器中，而不被提供给接收缓冲器。 响应于交换端口检测到来自接收机的确认分组，第二数据量从交换机端口缓冲器发送到接收缓冲器。