公开(公告)号：US09782520B2

公开(公告)日：2017-10-10

申请号：US14347551

申请日：2012-09-26

申请人： BioSpheres, Inc.

发明人： William Wustenberg ,  Michael Finch ,  Cyrus B. Munshi

IPC分类号： A61L31/10 ,  A61L31/04 ,  A61K45/06 ,  A61K31/745 ,  A61K9/14 ,  A61L15/46 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L17/00 ,  A61K9/51 ,  A61K9/16

CPC分类号： A61L31/10 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/745 ,  A61K45/06 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/12

摘要： Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.

公开(公告)号：US20180154050A1

公开(公告)日：2018-06-07

申请号：US15712859

申请日：2017-09-22

申请人： Biospheres, Inc.

发明人： William Wustenberg ,  Michael D. Finch ,  Cyrus B. Munshi

IPC分类号： A61L31/10 ,  A61L31/04 ,  A61K9/16 ,  A61K9/51 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L15/46 ,  A61L17/00 ,  A61K9/14 ,  A61K31/745 ,  A61K45/06

CPC分类号： A61L31/10 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/745 ,  A61K45/06 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/12

摘要： Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.

公开(公告)号：US09987396B1

公开(公告)日：2018-06-05

申请号：US15712859

申请日：2017-09-22

申请人： Biospheres, Inc.

发明人： William Wustenberg ,  Michael D Finch ,  Cyrus B. Munshi

IPC分类号： A61L31/10 ,  A61K9/14 ,  A61K45/06 ,  A61K9/51 ,  A61K31/745 ,  A61L15/46 ,  A61K9/16 ,  A61L29/16 ,  A61L17/00 ,  A61L31/16 ,  A61L27/54 ,  A61L31/04

CPC分类号： A61L31/10 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/745 ,  A61K45/06 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/12

摘要： Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.

公开(公告)号：US20150125505A1

公开(公告)日：2015-05-07

申请号：US14347551

申请日：2012-09-26

申请人： BioSpheres, Inc.

发明人： William Wustenberg ,  Michael Finch ,  Cyrus B. Munshi

IPC分类号： A61L31/10 ,  A61L31/04 ,  A61K45/06 ,  A61L31/16 ,  A61K9/14 ,  A61K31/745

CPC分类号： A61L31/10 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/745 ,  A61K45/06 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/12

摘要： Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.

摘要翻译： 讨论了用于刺激感染免疫应答的组合物，植入装置和方法。 在一些实例中，调节对感染的适应性免疫应答的扩增的组合物，植入装置或方法涉及在手术或植入部位局部使用一种或多种颗粒来控制细菌感染而没有有害的全身副作用。 在一些实例中，可以将颗粒涂覆或层压到可植入装置或材料的表面上。 在其他实例中，可将颗粒注入植入位点。