知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

24 records (took 0.034 seconds)

    SP35 Antibodies And Uses Thereof
    1.
    发明申请
    SP35 Antibodies And Uses Thereof 审中-公开

    公开(公告)号：US20200317775A1

    公开(公告)日：2020-10-08

    申请号：US16789738

    申请日：2020-02-13

    Applicant: Biogen MA Inc.

    Inventor： Sha Mi ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Ellen A. Garber Stark ,  Steven D. Miklasz ,  Christilyn Graff

    IPC: C07K16/28

    Abstract: Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

    SP35 Antibodies And Uses Thereof
    3.
    发明申请
    SP35 Antibodies And Uses Thereof 审中-公开

    公开(公告)号：US20190161546A1

    公开(公告)日：2019-05-30

    申请号：US16018819

    申请日：2018-06-26

    Applicant: Biogen MA Inc.

    Inventor： Sha Mi ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Ellen A. Garber Stark ,  Steven D. Miklasz ,  Christilyn Graff

    IPC: C07K16/28

    Abstract: Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

    Methods of Preventing and Removing Trisulfide Bonds
    10.
    发明申请
    Methods of Preventing and Removing Trisulfide Bonds 审中-公开
    防止和清除三硫键的方法

    公开(公告)号：US20150274808A1

    公开(公告)日：2015-10-01

    申请号：US14638215

    申请日：2015-03-04

    Applicant: BIOGEN MA INC.

    Inventor： David Evans ,  R. Blake Pepinsky ,  Dingyi Wen ,  Rashmi Rohit Kshirsagar ,  Karin Lucas

    IPC: C07K16/00

    CPC classification number: C07K16/00 ,  C07K1/1133

    Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.

    Abstract translation: 本发明涉及在蛋白质如抗体中预防和消除三硫键的方法。 在一个实施方案中，作为色谱纯化方法的一部分，将蛋白质中的三硫键转化为二硫键。 在另一个实施方案中，通过在这些蛋白质的细胞培养生产期间实施本文所述的方法来抑制蛋白质中三硫键的形成。 在另一个实施方案中，通过本文所述的方法产生单克隆抗体。

Patent Agency Ranking