公开(公告)号：US11773142B2

公开(公告)日：2023-10-03

申请号：US16772045

申请日：2018-12-11

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Dan H. Barouch ,  Peter Abbink ,  Mark Justin Iampietro ,  Menzo J. E. Havenga

IPC: C07K14/075 ,  A61K35/761 ,  A61K39/235 ,  A61K31/7088 ,  C07K14/54 ,  C12N15/861

CPC classification number: C07K14/075 ,  A61K31/7088 ,  A61K35/761 ,  A61K39/235 ,  C07K14/5425 ,  C12N15/861

Abstract: Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).