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    Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
    1.
    发明申请
    Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof 审中-公开
    用于口服给药的微管蛋白抑制剂靛蓝的药物制剂具有改善的药代动力学性质，及其制备方法

    公开(公告)号：US20060280787A1

    公开(公告)日：2006-12-14

    申请号：US11151459

    申请日：2005-06-14

    申请人： Berthold Roessler ,  Gerhard Raab ,  Thomas Reissmann

    发明人： Berthold Roessler ,  Gerhard Raab ,  Thomas Reissmann

    IPC分类号： A61K9/48 ,  A61K9/20

    CPC分类号： A61K9/1623 ,  A61K9/1652 ,  A61K31/4439 ,  Y02A50/465

    摘要： The present invention relates to a pharmaceutical formulation for oral administration of the poorly soluble and therefore hardly bioavailable microtubule polymerization inhibitor Indibulin and a process for its manufacture. In particular, there is provided a pharmaceutical formulation of Indibulin for oral administration comprising a granulate containing micronized Indibulin having a particle size of less than 20 μm for at least 99% of the volume of particles, at least one hydrophilic surfactant, and at least one capsulation excipient. The present invention also discloses a method of treating hyperproliferative disorders, malignancies and neoplasms with Indibulin.

    摘要翻译： 本发明涉及用于口服不溶性且因此难以生物利用的微管阻聚剂靛红纤维素的药物制剂及其制备方法。 特别地，提供了用于口服给药的靛蓝纤维素的药物制剂，其包含含有至少99％体积的颗粒，至少一种亲水性表面活性剂和至少一种亲水性表面活性剂的粒径小于20μm的微粉化靛蓝的颗粒 封装赋形剂。 本发明还公开了用靛蓝蛋白治疗过度增殖性疾病，恶性肿瘤和肿瘤的方法。

    Method, Arrangement and Monitoring Device for Navigation of Aircraft and Ground Vehicles Using Satellite-Assisted Positioning
    4.
    发明申请
    Method, Arrangement and Monitoring Device for Navigation of Aircraft and Ground Vehicles Using Satellite-Assisted Positioning 审中-公开
    使用卫星定位的飞机和地面车辆导航方法，布置和监测装置

    公开(公告)号：US20080270020A1

    公开(公告)日：2008-10-30

    申请号：US12092493

    申请日：2006-10-05

    申请人： Gerhard Raab

    发明人： Gerhard Raab

    IPC分类号： G08G5/06

    CPC分类号： G08G5/0013 ,  G08G5/025 ,  G08G5/065

    摘要： On reaching an approach area to a destination airport, the aircraft is provided with up-to-date topographical information and route information in addition to a destination position on the ground. Wireless communication technologies, such as GSM, GPRS, UMTS, WLan, WiMax, and the like are used to transmit this information. Advantageously, the transmitted information can be displayed on a commercially available navigation system on board the aircraft and can be used for navigation on the ground.

    摘要翻译： 在到达目的地机场的接近区域时，飞机除了在地面上的目的地位置之外还提供最新的地形信息和路线信息。 使用诸如GSM，GPRS，UMTS，WLan，WiMax等的无线通信技术来传送该信息。 有利地，所发送的信息可以在飞机上的市售导航系统上显示，并且可以用于地面上的导航。