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公开(公告)号：US11673951B2
公开(公告)日：2023-06-13
申请号：US16684237
申请日：2019-11-14
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2803 , A61K39/39591 , C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/70 , C07K2317/71 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.
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公开(公告)号：US11186637B2
公开(公告)日：2021-11-30
申请号：US17154696
申请日：2021-01-21
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.
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公开(公告)号：US11701357B2
公开(公告)日：2023-07-18
申请号：US16326467
申请日：2017-08-18
发明人： Nan Hu , Lai Wang , Jing Song , Tong Zhang , Kang Li , Lusong Luo , Min Wei , Zhiwei Wang , Yunhang Guo
IPC分类号： A61K31/519 , A61P35/00 , A61K39/395 , A61K39/00
CPC分类号： A61K31/519 , A61K39/3955 , A61P35/00 , A61K2039/505
摘要： Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. Also, disclosed a pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a targeted therapy agent and the use thereof.
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