公开(公告)号：US20230192626A1

公开(公告)日：2023-06-22

申请号：US17999408

申请日：2021-05-26

申请人： Baylor College of Medicine

发明人： Jin Wang ,  Hui Zheng ,  Lisheng Deng ,  Anamitra Ghosh

IPC分类号： C07D235/18 ,  C07D235/14 ,  C07D235/30 ,  C07D235/26 ,  C07D235/20 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D417/04 ,  C07D413/10 ,  C07D401/10 ,  C07D403/10 ,  C07D401/12 ,  C07D403/12 ,  C07D487/04 ,  C07D413/12 ,  C07D471/04 ,  C07D473/40 ,  C07D473/34 ,  A61K45/06

CPC分类号： C07D235/18 ,  C07D235/14 ,  C07D235/30 ,  C07D235/26 ,  C07D235/20 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D417/04 ,  C07D413/10 ,  C07D401/10 ,  C07D403/10 ,  C07D401/12 ,  C07D403/12 ,  C07D487/04 ,  C07D413/12 ,  C07D471/04 ,  C07D473/40 ,  C07D473/34 ,  A61K45/06

摘要： Novel soluble epoxide hydrolase (sEH) inhibitors are provided, along with methods for their use. The soluble epoxide hydrolase inhibitors are useful in treating and/or preventing sEH-related related diseases, such as Alzheimer's disease and inflammation. Also provided are methods for inhibiting soluble epoxide hydrolase in a cell using the compounds and compositions described herein.