-
公开(公告)号：US09958456B2
公开(公告)日：2018-05-01
申请号：US14350186
申请日：2012-10-04
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： Michael Thiele , Randolf J. Kerschbaumer , Dirk Voelkel , Patrice Douillard , Friedrich Scheiflinger
CPC分类号： G01N33/6863 , C07K16/24 , G01N2800/70
摘要： The present invention pertains to the recognition that a specific oxMIF form of MIF is useful as a diagnostic marker in (MIF-related) diseases, in particular for example monitoring of disease progression. The present invention also pertains to the respective use of a diagnostic kit and a respective diagnostic assay and pertains to advantageous respective antibodies.
-
公开(公告)号：US20170210794A1
公开(公告)日：2017-07-27
申请号：US15252100
申请日：2016-08-30
申请人： Baxalta Incorporated , Baxalta GmbH
CPC分类号： C07K16/24 , C07K2317/14 , C12N5/00 , C12N9/90 , C12N2510/00 , C12Y503/03012 , G01N33/6854 , G01N33/6863 , G01N2333/52
摘要： The present invention is concerned with the specific and highly sensitive detection of specific CHO-MIF complexes in the production of anti-MIF antibodies. The present invention is further concerned with the provision of specific antibodies which can be used for a CHO-MIF detection method.The present invention is also concerned with a CHO MIF knock-out cell line and use thereof. The present invention also provides preparations obtained from recombinant production in CHO cell lines which are essentially free of CHO-MIF.
-
公开(公告)号：US20210187105A1
公开(公告)日：2021-06-24
申请号：US17139772
申请日：2020-12-31
申请人： Baxalta Incorporated , Baxalta GmbH
IPC分类号： A61K39/395 , A61K31/56 , A61K31/58 , A61K31/573 , C07K16/24
摘要： The present invention pertains to anti-MIF antibodies, in particular their use in combination with glucocorticoids, in the treatment of glucocorticoid receptive diseases.
-
公开(公告)号：US20180280501A1
公开(公告)日：2018-10-04
申请号：US15801260
申请日：2017-11-01
申请人： Baxalta Incorporated , Baxalta GmbH
IPC分类号： A61K39/395 , A61K31/573 , C07K16/24 , A61K31/56 , A61K31/58
摘要： The present invention pertains to anti-MIF antibodies, in particular their use in combination with glucocorticoids, in the treatment of glucocorticoid receptive diseases.
-
公开(公告)号：US20190194351A1
公开(公告)日：2019-06-27
申请号：US16301962
申请日：2017-05-16
申请人： Baxalta Incorporated , Baxalta GmbH
IPC分类号： C07K16/36 , G01N33/573
CPC分类号： C07K16/36 , C07K16/005 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2319/21 , C07K2319/43 , G01N33/573 , G01N33/86 , G01N2333/9645
摘要： Provided herein are anti-Factor IX Padua binding constructs, e.g., antibodies and antigen-binding fragments thereof. Related polypeptides, conjugates and kits are also provided. The inventions may be used in methods of detecting Factor IX Padua in a sample.
-
公开(公告)号：US20180215807A1
公开(公告)日：2018-08-02
申请号：US15505894
申请日：2015-08-21
申请人： Baxalta GmbH , Baxalta Incorporated
CPC分类号： C07K16/065 , C07K16/24 , C07K2317/14 , C07K2317/30 , G01N33/6863
摘要： The invention concerns a detection method to enable the detection of complexes formed between antibodies and antigen which is endogenous to the production cell line, e.g. CHO MIF in a final product.
-
公开(公告)号：US09465037B2
公开(公告)日：2016-10-11
申请号：US14350187
申请日：2012-10-04
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： Randolf J. Kerschbaumer , Dirk Voelkel , Gerhard Antoine , Friedrich Scheiflinger , Geert C. Mudde
CPC分类号： C07K16/24 , C07K2317/14 , C12N5/00 , C12N9/90 , C12N2510/00 , C12Y503/03012 , G01N33/6854 , G01N33/6863 , G01N2333/52
摘要： The present invention is concerned with the specific and highly sensitive detection of specific CHO-MIF (macrophage migration inhibitory factor from Chinese Ovarian Hamster cell line) complexes in the production of anti-MIF antibodies. The present invention is further concerned with the provision of specific antibodies which can be used for a CHO-MIF detection method. The present invention is also concerned with a CHO MIF knockout cell line and use thereof. The present invention also provides preparations obtained from recombinant production in CHO cell lines which are essentially free of CHO-MIF.
摘要翻译： 本发明涉及特异性和高度灵敏的检测特异性CHO-MIF（来自中国卵巢仓鼠细胞系的巨噬细胞迁移抑制因子）复合物在抗MIF抗体的产生中的作用。 本发明还涉及提供可用于CHO-MIF检测方法的特异性抗体。 本发明还涉及CHO MIF敲除细胞系及其用途。 本发明还提供了基本上不含CHO-MIF的CHO细胞系中重组生产获得的制剂。
-
公开(公告)号：US20200207840A1
公开(公告)日：2020-07-02
申请号：US16817392
申请日：2020-03-12
摘要： The invention concerns a detection method to enable the detection of complexes formed between antibodies and antigen which is endogenous to the production cell line, e.g. CHO MIF in a final product.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.015 秒)
