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公开(公告)号：US10696676B2
公开(公告)日：2020-06-30
申请号：US16583869
申请日：2019-09-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yam B. Poudel , Sanjeev Gangwar , Prasanna Sivaprakasam , Shoshana L. Posy
IPC: C07D473/18 , A61P37/04
Abstract: Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10981914B2
公开(公告)日：2021-04-20
申请号：US16578733
申请日：2019-09-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ian S. Young , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
IPC: C07D473/18 , C07D473/04
Abstract: Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5 X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10793569B2
公开(公告)日：2020-10-06
申请号：US16865009
申请日：2020-05-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
IPC: A61K31/52 , A61K31/522 , C07D473/18 , C07D473/04 , A61P37/04 , A61K47/68
Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10457681B2
公开(公告)日：2019-10-29
申请号：US16103511
申请日：2018-08-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ian S. Young , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
IPC: C07D473/18 , C07D473/04
Abstract: Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10913741B2
公开(公告)日：2021-02-09
申请号：US17003385
申请日：2020-08-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
IPC: A61K31/52 , A61K31/522 , C07D473/18 , C07D473/04 , A61P37/04 , A61K47/68
Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R1, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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Patent Agency Ranking
6.发明授权公开(公告)号：US10898578B2
公开(公告)日：2021-01-26
申请号：US16425596
申请日：2019-05-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yam B. Poudel , Sanjeev Gangwar
Abstract: Compounds represented by formula (I) can be used to make antibody-drug conjugates. The conjugates so made are stable in both human and mouse serum, enabling the performance of pre-clinical studies using a mouse model.
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公开(公告)号：US10889590B2
公开(公告)日：2021-01-12
申请号：US16357109
申请日：2019-03-18
Applicant: WILLIAM MARSH RICE UNIVERSITY , BRISTOL-MYERS SQUIBB COMPANY , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Kyriacos C. Nicolaou , Min Lu , Debashis Mandal , Sanjeev Gangwar , Naidu S. Chowdari , Yam B. Poudel
IPC: C07D491/08 , A61K47/68
Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
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8.发明申请公开(公告)号：US20200291028A1
公开(公告)日：2020-09-17
申请号：US16890765
申请日：2020-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yam B. Poudel , Sanjeev Gangwar , Prasanna Sivaprakasam , Shoshana L. Posy
IPC: C07D473/18 , A61P37/04
Abstract: Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10711003B2
公开(公告)日：2020-07-14
申请号：US16659735
申请日：2019-10-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Liqi He , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
IPC: A61K31/52 , C07D473/18 , A61P37/04 , A61K47/60 , A61K47/68
Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10472361B2
公开(公告)日：2019-11-12
申请号：US16103210
申请日：2018-08-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yam B. Poudel , Sanjeev Gangwar , Prasanna Sivaprakasam , Shoshana L. Posy
IPC: C07D473/18 , A61P37/04
Abstract: Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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