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公开(公告)号：US20230390249A1
公开(公告)日：2023-12-07
申请号：US18453431
申请日：2023-08-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC: A61K31/4192 , C07D401/14 , C07D249/06 , A61K31/27 , A61K31/454 , C07D401/04
CPC classification number: A61K31/4192 , C07D401/14 , C07D249/06 , A61K31/27 , A61K31/454 , C07D401/04 , A61K31/41
Abstract: The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.-
公开(公告)号：US10577383B2
公开(公告)日：2020-03-03
申请号：US16099010
申请日：2017-06-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joanne M. Smallheer , Ellen K. Kick , Meriah Neissel Valente , Carol Hui Hu , Oz Scott Halpern , Sutjano Jusuf
IPC: C07D519/00 , A61P9/10
Abstract: The present invention provides compounds of Formula (I): wherein the substituents are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US20170360759A1
公开(公告)日：2017-12-21
申请号：US15628104
申请日：2017-06-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun LI , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC: A61K31/4192 , A61K31/27 , C07D401/04 , A61K31/454 , C07C62/10 , A61K31/41
CPC classification number: A61K31/4192 , A61K31/27 , A61K31/41 , A61K31/454 , C07C62/10 , C07D249/06 , C07D401/04 , C07D401/14
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20210230143A1
公开(公告)日：2021-07-29
申请号：US16772825
申请日：2018-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Shi , Ying Wang , Peter Tai Wah Cheng , Jun Shi , Shiwei Tao , James R. Corte , Tianan Fang , Jun Li , Lawrence J. Kennedy , Robert F. Kaltenbach, III , Sutjano Jusuf
IPC: C07D401/14 , C07D409/14 , C07D403/14 , C07D401/12 , C07D405/14 , C07D491/052
Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20170253554A1
公开(公告)日：2017-09-07
申请号：US15509214
申请日：2015-09-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Shi , Peter T.W. Cheng , Ying Wang , Sutjano Jusuf , Shiwei Tao , Hao Zhang , Shung C. Wu , Jeffrey A. Robl
IPC: C07C62/34 , A61K31/192 , C07D307/79 , A61K31/343 , C07D277/30 , A61K31/44 , C07D213/55 , A61K31/4418 , C07D231/12 , A61K31/415 , C07D213/65 , A61K45/06 , A61K31/426
CPC classification number: C07C62/34 , A61K31/192 , A61K31/343 , A61K31/415 , A61K31/426 , A61K31/44 , A61K31/4418 , C07C59/64 , C07C2601/02 , C07D207/323 , C07D213/55 , C07D213/65 , C07D231/12 , C07D277/30 , C07D277/593 , C07D307/79 , C07D307/82
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulators which may be used as medicaments
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Patent Agency Ranking
公开(公告)号：USRE49352E1
公开(公告)日：2023-01-03
申请号：US17011592
申请日：2020-09-03
Applicant: Bristol-Myers Squibb Company
Inventor： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Badu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC: A61K31/4192 , A61K31/27 , A61K31/454 , C07D249/06 , C07D401/04 , C07D401/14 , A61K31/41 , C07C62/10
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US11007180B2
公开(公告)日：2021-05-18
申请号：US16732387
申请日：2020-01-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC: C07D401/04 , A61K31/4192 , C07D401/14 , C07D249/06 , A61K31/27 , A61K31/454 , A61K31/41 , C07C62/10
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20200291016A1
公开(公告)日：2020-09-17
申请号：US16083958
申请日：2017-03-16
Applicant: Bristol-Myers Squibb Company
Inventor： Ellen K. Kick , Joanne M. Smalheer , Scott A. Shaw , Benjiman P. Vokits , Andrew K. Dilger , Charles G. Clark , Meriah Neissel Valente , Sutjano Jusuf , Nicholas R. Wurtz
IPC: C07D471/04 , C07D519/00
Abstract: The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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公开(公告)号：US10071078B2
公开(公告)日：2018-09-11
申请号：US15628104
申请日：2017-06-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC: C07D401/04 , A61K31/4192 , A61K31/27 , A61K31/454 , C07D401/14 , C07D249/06 , A61K31/41 , C07C62/10
CPC classification number: A61K31/4192 , A61K31/27 , A61K31/41 , A61K31/454 , C07C62/10 , C07D249/06 , C07D401/04 , C07D401/14
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20250057815A1
公开(公告)日：2025-02-20
申请号：US18822597
申请日：2024-09-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter Tai Wah Cheng , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC: A61K31/4192 , A61K31/27 , A61K31/41 , A61K31/454 , C07C62/10 , C07D249/06 , C07D401/04 , C07D401/14
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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