公开(公告)号：US20200308172A1

公开(公告)日：2020-10-01

申请号：US16955097

申请日：2018-12-18

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckma ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  John P. Gilmore ,  Tasir Shmsul Haque ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  Shoshana L. Posy ,  Sreekantha Ratna Kumar ,  Laxman Warangal ,  Srinivasan Kunchythapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula ,  Pitani Veera Venkata Sriniva

IPC分类号： C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  C07D453/02 ,  C07D491/08 ,  C07D401/04 ,  C07D401/10

摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.