公开(公告)号：US20160243125A1

公开(公告)日：2016-08-25

申请号：US15027585

申请日：2014-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Carolyn Diane Dzierba ,  Bireshwar Dasgupta ,  John E. Macor ,  Joanne J. Bronson ,  Ramkumar Rajamani ,  George N. Karageorge

IPC: A61K31/53 ,  A61K31/5377

CPC classification number: A61K31/53 ,  A61K31/5377

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。

公开(公告)号：US08841301B2

公开(公告)日：2014-09-23

申请号：US13625015

申请日：2012-09-24

Applicant: Bristol-Myers Squibb Company

Inventor： Dalton King ,  John E. Macor ,  Richard E. Olson ,  Christiana I. Iwuagwu ,  George N. Karageorge

IPC: C07D403/12 ,  C07D413/12 ,  A61K31/536 ,  A61K31/4709

CPC classification number: C07D401/12 ,  C07D239/42 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US09737542B2

公开(公告)日：2017-08-22

申请号：US15027585

申请日：2014-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Carolyn Diane Dzierba ,  Bireshwar Dasgupta ,  John E. Macor ,  Joanne J. Bronson ,  Ramkumar Rajamani ,  George N. Karageorge

IPC: A61K31/53 ,  A61K31/5377

CPC classification number: A61K31/53 ,  A61K31/5377

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US20130079338A1

公开(公告)日：2013-03-28

申请号：US13625015

申请日：2012-09-24

Applicant: Bristol-Myers Squibb Company

Inventor： Dalton King ,  John E. Macor ,  Richard E. Olson ,  Christiana I. Iwuagwu ,  George N. Karageorge

IPC: C07D401/12 ,  C07D239/22 ,  A61K31/506 ,  C07D403/12 ,  A61P25/16 ,  A61K31/536 ,  A61P25/24 ,  A61P25/28 ,  A61P25/00 ,  A61K31/4709 ,  C07D413/12

CPC classification number: C07D401/12 ,  C07D239/42 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.