公开(公告)号：US20180099949A1

公开(公告)日：2018-04-12

申请号：US15840198

申请日：2017-12-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Elizabeth A. Jurica ,  Zhenqiu Hong

IPC: C07D401/14 ,  C07D401/12 ,  A61K31/4545 ,  A61K31/454 ,  A61K45/06 ,  A61K31/506

CPC classification number: C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/06 ,  C07D401/12

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US09133163B2

公开(公告)日：2015-09-15

申请号：US14081094

申请日：2013-11-15

Applicant: Bristol-Myers Squibb Company

Inventor： Bruce A. Ellsworth ,  Jun Shi ,  William R. Ewing ,  Elizabeth A. Jurica ,  Andres S. Hernandez ,  Ximao Wu

IPC: C07D401/14 ,  C07D401/12 ,  A61K31/454 ,  A61K45/06 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D401/12 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR40G蛋白偶联受体调节剂。

公开(公告)号：US09714231B2

公开(公告)日：2017-07-25

申请号：US14442642

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Elizabeth A. Jurica ,  Jun Shi ,  William R. Ewing ,  Xiang-Yang Ye ,  Ximao Wu ,  Zhu Yeheng ,  Sun Chongqing

IPC: A61K31/4025 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  A61K45/06 ,  C07D207/08 ,  C07D207/12 ,  C07D401/10

CPC classification number: C07D401/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/506 ,  A61K45/06 ,  C07D207/08 ,  C07D207/12 ,  C07D401/10 ,  C07D401/14 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US20170081282A1

公开(公告)日：2017-03-23

申请号：US15308459

申请日：2015-05-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiang-Yang Ye ,  Bruce A. Ellsworth ,  Elizabeth A. Jurica

IPC: C07D207/08 ,  A61K31/40 ,  C07D207/16 ,  A61K31/422 ,  C07D401/04 ,  A61K31/4439 ,  C07D413/04 ,  A61K45/06 ,  C07D207/12

CPC classification number: C07D207/08 ,  A61K31/40 ,  A61K31/422 ,  A61K31/4439 ,  A61K45/06 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D401/04 ,  C07D413/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US10301260B2

公开(公告)日：2019-05-28

申请号：US15308459

申请日：2015-05-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiang-Yang Ye ,  Bruce A. Ellsworth ,  Elizabeth A. Jurica

IPC: C07D207/08 ,  C07D401/04 ,  C07D413/04 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  A61K45/06 ,  A61K31/40 ,  A61K31/422 ,  A61K31/4439

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US20160297797A1

公开(公告)日：2016-10-13

申请号：US14442670

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Jun Shi ,  William R. Ewing ,  Elizabeth A. Jurica ,  Andres S. Hernandez ,  Ximao Wu ,  Zhengxiang Gu ,  Zhenqiu Hong ,  Stephen P. O'Connor

IPC: C07D401/12 ,  A61K31/454 ,  C07D451/06 ,  A61K31/46 ,  C07D405/14 ,  C07D401/14 ,  A61K31/506 ,  C07D417/14 ,  C07D403/12 ,  A61K31/55 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/4155 ,  C07D471/08 ,  C07D413/14 ,  A61K45/06

CPC classification number: C07D401/12 ,  A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US20150322044A1

公开(公告)日：2015-11-12

申请号：US14705524

申请日：2015-05-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Elizabeth A. Jurica ,  Zhenqiu Hong

IPC: C07D401/14 ,  A61K31/506 ,  C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06

CPC classification number: C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/06 ,  C07D401/12

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

Abstract translation: 本发明提供式（I）的化合物或其立体异构体，互变异构体，药学上可接受的盐，多晶型物或溶剂化物，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR40G蛋白偶联受体调节剂。

公开(公告)号：US09873679B2

公开(公告)日：2018-01-23

申请号：US14705524

申请日：2015-05-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Elizabeth A. Jurica ,  Zhenqiu Hong

IPC: A61K31/505 ,  C07D401/14 ,  A61K31/4545 ,  A61K45/06 ,  A61K31/454 ,  A61K31/506 ,  C07D401/12

CPC classification number: C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/06 ,  C07D401/12

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US09604964B2

公开(公告)日：2017-03-28

申请号：US14442670

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Jun Shi ,  William R. Ewing ,  Elizabeth A. Jurica ,  Andres S. Hernandez ,  Ximao Wu ,  Zhengxiang Gu ,  Zhenqiu Hong ,  Stephen P. O'Connor

IPC: C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14 ,  C07D403/12 ,  C07D451/06 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/4155 ,  C07D413/14 ,  C07D401/10 ,  C07D487/08 ,  A61K31/454 ,  A61K31/46 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  C07D471/08

CPC classification number: C07D401/12 ,  A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US20160280680A1

公开(公告)日：2016-09-29

申请号：US14442642

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Elizabeth A. Jurica ,  Jun Shi ,  William R. Ewing ,  Xiang-Yang Ye ,  Ximao Wu ,  Zhu Yeheng ,  Sun Chongqing

IPC: C07D401/12 ,  C07D207/08 ,  A61K31/4025 ,  C07D207/12 ,  A61K45/06 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/506 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/454 ,  C07D401/10

CPC classification number: C07D401/12 ,  A61K31/4025 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/506 ,  A61K45/06 ,  C07D207/08 ,  C07D207/12 ,  C07D401/10 ,  C07D401/14 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.