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公开(公告)号：US20230303538A1
公开(公告)日：2023-09-28
申请号：US17927426
申请日：2021-05-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： CHUNJIAN LIU , Wei Wang , Bruce A. Ellsworth , James Aaron Balog , Alicia Regueiro-Ren
IPC: C07D405/14
CPC classification number: C07D405/14
Abstract: The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
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公开(公告)号：US09656963B2
公开(公告)日：2017-05-23
申请号：US14442624
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Andres S. Hernandez , Bruce A. Ellsworth , William R. Ewing , Bin Chen
IPC: C07D231/06 , C07D403/12 , C07D231/08 , C07D401/10 , C07D403/04 , C07D401/04 , C07D401/12 , C07D403/10 , C07D413/04 , A61K45/06 , A61K31/4155 , A61K31/415 , A61K31/506 , A61K31/497 , A61K31/422 , A61K31/4439
CPC classification number: C07D231/06 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K45/06 , C07D231/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/04 , A61K2300/00
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US09604964B2
公开(公告)日：2017-03-28
申请号：US14442670
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bruce A. Ellsworth , Jun Shi , William R. Ewing , Elizabeth A. Jurica , Andres S. Hernandez , Ximao Wu , Zhengxiang Gu , Zhenqiu Hong , Stephen P. O'Connor
IPC: C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/14 , C07D403/12 , C07D451/06 , A61K45/06 , A61K31/4545 , A61K31/4155 , C07D413/14 , C07D401/10 , C07D487/08 , A61K31/454 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , C07D471/08
CPC classification number: C07D401/12 , A61K31/4155 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20160280680A1
公开(公告)日：2016-09-29
申请号：US14442642
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bruce A. Ellsworth , Elizabeth A. Jurica , Jun Shi , William R. Ewing , Xiang-Yang Ye , Ximao Wu , Zhu Yeheng , Sun Chongqing
IPC: C07D401/12 , C07D207/08 , A61K31/4025 , C07D207/12 , A61K45/06 , C07D401/14 , A61K31/4545 , A61K31/506 , C07D487/04 , A61K31/5025 , A61K31/454 , C07D401/10
CPC classification number: C07D401/12 , A61K31/4025 , A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/08 , C07D207/12 , C07D401/10 , C07D401/14 , C07D487/04
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20220185800A1
公开(公告)日：2022-06-16
申请号：US17439845
申请日：2020-03-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Chunjian Liu , David S. Yoon , Wei Wang , Jianxin Feng , Bruce A. Ellsworth , Alicia Regueiro-Ren
IPC: C07D405/14 , C07D417/14
Abstract: The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
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Patent Agency Ranking
公开(公告)号：US20160280659A1
公开(公告)日：2016-09-29
申请号：US14442624
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Andres S. Hernandez , Bruce A. Ellsworth , William R. Ewing , Bin Chen
IPC: C07D231/06 , C07D231/08 , C07D403/04 , A61K31/4155 , C07D413/04 , A61K31/422 , C07D401/12 , A61K31/4439 , C07D403/10 , A61K31/506 , C07D401/04 , C07D403/12 , C07D401/10 , A61K31/497 , A61K45/06 , A61K31/415
CPC classification number: C07D231/06 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K45/06 , C07D231/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/04 , A61K2300/00
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR40G蛋白偶联受体调节剂。
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公开(公告)号：US09133163B2
公开(公告)日：2015-09-15
申请号：US14081094
申请日：2013-11-15
Applicant: Bristol-Myers Squibb Company
Inventor： Bruce A. Ellsworth , Jun Shi , William R. Ewing , Elizabeth A. Jurica , Andres S. Hernandez , Ximao Wu
IPC: C07D401/14 , C07D401/12 , A61K31/454 , A61K45/06 , A61K31/4545 , A61P3/10
CPC classification number: C07D401/12 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR40G蛋白偶联受体调节剂。
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公开(公告)号：US20220144818A1
公开(公告)日：2022-05-12
申请号：US17601942
申请日：2020-04-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Chunjian Liu , Jianxin Feng , Pratik Devasthale , Natesan Murugesan , Bruce A. Ellsworth , Alicia Regueiro-Ren , Susheel Jethanand Nara , Prasada Rao Jalagam , Manoranjan Panda
IPC: C07D417/14 , C07D405/04 , C07D405/14 , C07D409/14
Abstract: The present disclosure relates to compounds of Formula (I) or (II), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
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公开(公告)号：US10301260B2
公开(公告)日：2019-05-28
申请号：US15308459
申请日：2015-05-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xiang-Yang Ye , Bruce A. Ellsworth , Elizabeth A. Jurica
IPC: C07D207/08 , C07D401/04 , C07D413/04 , C07D207/12 , C07D207/14 , C07D207/16 , A61K45/06 , A61K31/40 , A61K31/422 , A61K31/4439
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20160297797A1
公开(公告)日：2016-10-13
申请号：US14442670
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bruce A. Ellsworth , Jun Shi , William R. Ewing , Elizabeth A. Jurica , Andres S. Hernandez , Ximao Wu , Zhengxiang Gu , Zhenqiu Hong , Stephen P. O'Connor
IPC: C07D401/12 , A61K31/454 , C07D451/06 , A61K31/46 , C07D405/14 , C07D401/14 , A61K31/506 , C07D417/14 , C07D403/12 , A61K31/55 , A61K31/4545 , A61K31/497 , A61K31/4155 , C07D471/08 , C07D413/14 , A61K45/06
CPC classification number: C07D401/12 , A61K31/4155 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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