公开(公告)号：US20240310805A1

公开(公告)日：2024-09-19

申请号：US18442010

申请日：2024-02-14

Applicant: BOEHRINGER INGELHEIM RCV GMBH & CO KG ,  SANDOZ GMBH

Inventor： Alois Jungbauer ,  Astrid Durauer ,  Nicole Walch ,  Dominik Sauer ,  Theresa Scharl-Hirsch ,  Michael Melcher ,  Friedrich Leisch

IPC: G05B19/042 ,  G01N21/64 ,  G01N30/88 ,  G05B19/418

CPC classification number: G05B19/0428 ,  G01N21/6486 ,  G01N30/88 ,  G05B19/4183 ,  G05B19/41885

Abstract: The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.

公开(公告)号：US20210149361A1

公开(公告)日：2021-05-20

申请号：US16091095

申请日：2017-04-04

Applicant: BOEHRINGER INGELHEIM RCV GMBH & CO KG ,  SANDOZ AG

Inventor： Alois Jungbauer ,  Astrid Durauer ,  Nicole Walch ,  Dominik Sauer ,  Theresa Scharl-Hirsch ,  Michael Melcher ,  Friedrich Leisch

IPC: G05B19/042 ,  G05B19/418

Abstract: The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.