公开(公告)号：US20150283245A1

公开(公告)日：2015-10-08

申请号：US14435796

申请日：2013-08-05

申请人： BMI KOREA CO., LTD

发明人： Koo Woo ,  Ha-Na Kim ,  Yeong-Jun Baik ,  Sung-Hee Lee

IPC分类号： A61K47/34 ,  A61K9/00 ,  A61K47/18 ,  A61K38/47

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K38/47 ,  A61K47/10 ,  A61K47/183 ,  C12N9/2408 ,  C12N9/2474 ,  C12N9/96 ,  C12Y302/01035

摘要： This invention relates to a stable liquid formulation comprising hyaluronidase and a stabilizer for hyaluronidase and more particularly, to a stable liquid formulation by the addition of the stabilizer to the hyaluronidase.

摘要翻译： 本发明涉及包含透明质酸酶和透明质酸酶稳定剂的稳定液体制剂，更具体地说，涉及通过向透明质酸酶加入稳定剂而得到稳定的液体制剂。

公开(公告)号：US11602539B2

公开(公告)日：2023-03-14

申请号：US16327961

申请日：2017-09-06

申请人： BMI KOREA CO., LTD

发明人： Min-Kyoung Kim ,  Koo Woo ,  Yeong Jun Baik ,  Kyeong Woo Min

IPC分类号： A61K31/728 ,  A61K35/583 ,  A61K38/48 ,  A61P7/04 ,  C08B37/08

摘要： The present invention relates to a hemostatic composition and a method for preparing thereof, and more specifically, relates to a hemostatic composition comprising a cross-linked hyaluronic acid derivative matrix which is suitable to be used for hemostasis and a method of preparation of such a composition.

公开(公告)号：US10456347B2

公开(公告)日：2019-10-29

申请号：US15775855

申请日：2016-11-24

申请人： BMI KOREA CO., LTD

发明人： Min-Kyoung Kim ,  Koo Woo ,  Yeong Jun Baik ,  Sung Hee Lee ,  Kyeong Woo Min

IPC分类号： A61K8/73 ,  A61K31/728 ,  A61Q19/08 ,  C08B37/08 ,  C08J3/24 ,  A61K8/96 ,  A61K8/04 ,  A61L31/00 ,  C08L5/08 ,  A61K9/00

摘要： The present invention refers to the injectable hyaluronic acid composition which is crosslinked viscoelastic hyaluronic acid gel comprising DNA fractions. More particularly, it refers to the injectable hyaluronic acid composition comprising a hyaluronic acid composition crosslinked in the basic conditions with the degree of crosslinking between 0.1 and 200%, which is mixed with the DNA fractions of 0.1 to 50 wt %. The DNA fractions are selected, for example, from polynucleotide (PN) and polydeoxyribonucleotide (PDRN). The composition used for cosmetic purposes or therapeutic purposes, have improved viscoelastic rheological properties and enzyme resistance.

公开(公告)号：US09682149B2

公开(公告)日：2017-06-20

申请号：US14435796

申请日：2013-08-05

申请人： BMI KOREA CO., LTD

发明人： Koo Woo ,  Ha-Na Kim ,  Yeong-Jun Baik ,  Sung-Hee Lee

IPC分类号： C12N9/26 ,  A61K47/34 ,  A61K38/47 ,  C12N9/96 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K38/47 ,  A61K47/10 ,  A61K47/183 ,  C12N9/2408 ,  C12N9/2474 ,  C12N9/96 ,  C12Y302/01035

摘要： This invention relates to a stable hyaluronidase liquid formulation comprising a hyaluronidase and a stabilizer for hyaluronidase. In particular, the hyaluronidase has a purity of 95% or more and the specific activity of 70,000 IU/mg or more, and the stabilizer for hyaluronidase contains a buffering agent in order to provide pH of 4.0 to 6.0; 0.001 to 0.5 v/v % of a non-ionic surfactant; and 0.1 to 5 mM of a chelating agent or MgCl2. The liquid formulation has advantages in that it stably maintains its activity for a long period of time and may be easily administered than the conventional formulations.