公开(公告)号：US20240367161A1

公开(公告)日：2024-11-07

申请号：US18654043

申请日：2024-05-03

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： PEYTON RUSSELBURG ,  BRIAN PANGANIBAN ,  DANNI WANG ,  JOSEPH POBLETE ,  ALEXANDER POLGAR

IPC: B01J43/00 ,  B01D15/38 ,  B01J47/02 ,  C07K1/22

Abstract: The subject invention pertains to multimodal chromatography resins comprising anionic and cationic ligands on each resin particle and methods of synthesizing the multimodal chromatography resin by contacting a base with quaternary amines and/or tertiary amines on the surface of a substrate. The multimodal resins can be tuned by changing the ratios of cation to anions. The multimodal chromatography resins can be used for purifying proteins.