公开(公告)号：US3528965A

公开(公告)日：1970-09-15

申请号：US3528965D

申请日：1968-02-09

Applicant: BEECHAM GROUP LTD

Inventor： COLE MARTIN ,  DOYLE FRANK PETER ,  SOULAL MAURICE JOHN

IPC: C07D499/00 ,  C07D499/32 ,  C07D99/14 ,  C07D99/16

CPC classification number: C07D499/00 ,  Y10S435/824 ,  Y10S435/829 ,  Y10S435/849 ,  Y10S435/873 ,  Y10S435/874

公开(公告)号：US3551448A

公开(公告)日：1970-12-29

申请号：US3551448D

申请日：1968-10-08

Applicant: BEECHAM GROUP LTD

Inventor： COLE MARTIN ,  ROLINSON GEORGE NEWBOLT

IPC: C07D207/40 ,  C07D207/404 ,  C07D27/10

CPC classification number: C07D207/408 ,  C07D207/40 ,  Y10S435/913

公开(公告)号：US4560552C1

公开(公告)日：2001-10-16

申请号：US33045681

申请日：1981-12-14

Applicant: BEECHAM GROUP LTD

Inventor： COLE MARTIN ,  HOWARTH THOMAS T ,  READING CHRISTOPHER

IPC: A61K31/42 ,  A61K31/43 ,  A61P31/04 ,  C07D503/00 ,  C12N9/99 ,  C12P1/06 ,  C12P17/18 ,  C12P37/04 ,  A61K35/00

CPC classification number: C12P17/188 ,  A61K31/42 ,  A61K31/43 ,  C07D503/00 ,  A61K2300/00

Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): (I) In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of beta -lactam antibiotics against many beta -lactamase producing bacteria.