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公开(公告)号：US20220056396A1
公开(公告)日：2022-02-24
申请号：US17310154
申请日：2020-01-21
Applicant: Becton, Dickinson and Company
Inventor： James R. Petisce , Adam Steel , Robert E. Armstrong , David J. Turner , Richard Ivey
Abstract: Provided herein are devices, systems, and methods for measuring the presence of an analyte of interest in a sample. Certain embodiments of the present disclosure are related to culture measurement systems that include a culture vial and a sensor, wherein the sensor is a pH sensor, a responsive label, or an indicator compound, such that the sensor is incorporated into the culture vial for measurement of the pH of the sample.
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公开(公告)号：US20210262936A1
公开(公告)日：2021-08-26
申请号：US17254794
申请日：2019-06-24
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： James R. Petisce , Robert E. Armstrong , David J. Turner
Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.
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Patent Agency Ranking
公开(公告)号：US20250102423A1
公开(公告)日：2025-03-27
申请号：US18730824
申请日：2023-02-03
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： James R. Petisce , Robert Edward Armstrong , Jingyun Zhang , Edward M. Skevington , Alexander W. Clark , Brent Ronald Pohl , David J. Turner
Abstract: A calibrator bottle and method of calibration. The calibrator bottle includes a plastic material that is doped or compounded with a fluorescent material system that fluoresces in a target range and may be used to calibrate a blood culture instrument that measures sample fluorescence to determine bottle positivity or negativity. Also described herein is a system and method to control the temperature of samples in a blood culture apparatus using a resistance temperature device (RTD) device that measures the temperature of the sample. The sample measurements are correlated with the ambient temperature to determine an ambient temperature that will provide a target bottle content temperature.
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4.发明授权公开(公告)号：US12234499B2
公开(公告)日：2025-02-25
申请号：US17705153
申请日：2022-03-25
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： William B. Brasso , David J. Turner , Susan M. Kircher , Fatimah Alrashidi-Brooks
Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.
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公开(公告)号：US11946865B2
公开(公告)日：2024-04-02
申请号：US17254794
申请日：2019-06-24
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： James R. Petisce , Robert E. Armstrong , David J. Turner
CPC classification number: G01N21/6428 , A61B5/0071 , C12M41/34 , C12M41/36 , C12M41/38 , C12M41/46 , G01N21/80 , G01N33/49
Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.
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公开(公告)号：US20240393246A1
公开(公告)日：2024-11-28
申请号：US18796851
申请日：2024-08-07
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： James R. Petisce , Robert E. Armstrong , David J. Turner
Abstract: A method of determining the presence of an analyte of interest in a blood sample within a test device including a sensor in aqueous media includes transmitting light to the test device at a first excitation wavelength at which light absorption of the sensor remains substantially constant as pH of the aqueous media changes, measuring an intensity of a first fluorescence signal emitted from the sensor in the test device in response to the first excitation wavelength, transmitting light to the test device at a second excitation wavelength, the second excitation wavelength being different from the first excitation wavelength, measuring an intensity of a second fluorescence signal emitted from the sensor in the test device in response to the second excitation wavelength, and normalizing, with the first fluorescence signal, the intensity of the second fluorescence signal emitted from the test device in response to the second excitation wavelength.
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7.发明授权公开(公告)号：US11286512B2
公开(公告)日：2022-03-29
申请号：US16313846
申请日：2017-06-26
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： William B. Brasso , David J. Turner , Susan M. Kircher , Fatimah Alrashidi-Brooks
Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.
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