公开(公告)号：US20210299224A1

公开(公告)日：2021-09-30

申请号：US17301123

申请日：2021-03-25

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： SangKon OH ,  Sandra ZURAWSKI ,  Hyemee JOO ,  Gerard ZURAWSKI

IPC: A61K38/20 ,  C07K14/54 ,  A61K39/00 ,  C07K16/28

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US20170349661A1

公开(公告)日：2017-12-07

申请号：US15501526

申请日：2015-08-03

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Yong-Jun LIU ,  Sandra ZURAWSKI ,  SangKon OH ,  Shino HANABUCHI ,  Haruyuki FUJITA ,  Hideki UENO ,  Patrick BLANCO ,  Hyemee JOO

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2875 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

Abstract: Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-α and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell- (Tfh) responses that may contribute to the pathogenicity of autoimmune disease.