公开(公告)号：US20230066401A1

公开(公告)日：2023-03-02

申请号：US17795941

申请日：2021-02-01

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Christopher Koradin ,  Roland Goetz ,  Harish Shinde

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base.

公开(公告)号：US20240101516A1

公开(公告)日：2024-03-28

申请号：US18272673

申请日：2022-01-17

Applicant: BASF SE

Inventor： Rahul Kaduskar ,  Kailaskumar Borate ,  Suyog Adhav ,  Saravanan Thirunavukkarasu ,  Harish Shinde ,  Roland Goetz

IPC: C07D213/75 ,  C07C231/12

CPC classification number: C07D213/75 ,  C07C231/12

Abstract: The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

公开(公告)号：US11021452B2

公开(公告)日：2021-06-01

申请号：US16634202

申请日：2018-07-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Wassilios Grammenos ,  Michael Rack ,  Kailaskumar Borate ,  Roland Goetz

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.

公开(公告)号：US20240327362A1

公开(公告)日：2024-10-03

申请号：US18576149

申请日：2022-06-28

Applicant: BASF SE

Inventor： Joachim Gebhardt ,  Guillaume Michel Jacques Garivet ,  Kailaskumar Borate ,  Daniel Maximilian Knoll ,  Roland Goetz

IPC: C07D271/06

CPC classification number: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted amidoximes of formula I, which can be obtained through reaction of nitrile compounds of formula II with free hydroxylamine in the presence of a solvent.

公开(公告)号：US20230145982A1

公开(公告)日：2023-05-11

申请号：US17796291

申请日：2021-02-01

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Christopher Koradin ,  Joachim Gebhardt ,  Roland Goetz ,  Harish Shinde

IPC: C07D271/06

CPC classification number: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula I, which can be obtained through reaction of amidoxime compounds of formula II with a haloacetic ester in the presence of a solvent and a base.

公开(公告)号：US20230100114A1

公开(公告)日：2023-03-30

申请号：US17917301

申请日：2021-04-06

Applicant: BASF SE

Inventor： Kailaskumar Borate ,  Saravanan Thirunavukkarasu ,  Rahul Kaduskar ,  Harish Shinde ,  Roland Goetz

IPC: C07C209/10 ,  B01J31/22 ,  B01J31/18

Abstract: The presently claimed invention relates to a process for the preparation of di-, tri-, or tetra fluoroarylamine by reacting polyfluorinated aryl chlorides with ammonia in the presence of a base, a metal catalyst and a ligand. Di-, tri-, tetrafluoroarylamines are valuable intermediates and find application in several areas, mainly in epoxy polymers, colorants, dyes, polyurethanes, agrochemicals and pharmaceutical active agents.

公开(公告)号：US20230028964A1

公开(公告)日：2023-01-26

申请号：US17779262

申请日：2020-11-25

Applicant: BASF SE

Inventor： Kailaskumar Borate ,  Bernd Wolf ,  Florian Vogt ,  Christopher Koradin ,  Roland Goetz ,  Harish Shinde

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted aromatic carboxamides of formula I, (formula I) which can be obtained through reaction of an aromatic carboxylic acid halide and an amine, whereas the process is conducted in the absence of an auxiliary base in a carboxylic acid ester as solvent.

公开(公告)号：US20210340113A1

公开(公告)日：2021-11-04

申请号：US17284199

申请日：2019-10-18

Applicant: BASF SE

Inventor： Karsten Koerber ,  Nikolas Huwyler ,  Arun Narine ,  Martin John McLaughlin ,  Kailaskumar Borate

IPC: C07D261/04 ,  C07D491/107

Abstract: The present invention relates to a process for preparing benzylic amides of formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 50% ee; by condensation of a ketone o formula (II) with an acetyl compound of formula (III) in the presence of a catalyst of formula (IV) wherein the variables are as defined in the specification.

公开(公告)号：US20200157064A1

公开(公告)日：2020-05-21

申请号：US16634202

申请日：2018-07-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Wassilios Grammenos ,  Michael Rack ,  Kailaskumar Borate ,  Roland Goetz

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.

公开(公告)号：US20230183171A1

公开(公告)日：2023-06-15

申请号：US17925873

申请日：2021-05-20

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Joachim Gebhardt ,  Guillaume Michel Jacques Garivet ,  Harish Shinde ,  Roland Goetz

IPC: C07C259/18 ,  C12P13/00 ,  C07D271/06

CPC classification number: C07C259/18 ,  C12P13/002 ,  C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 4-(N′-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).