公开(公告)号：US20230357129A1

公开(公告)日：2023-11-09

申请号：US17802171

申请日：2021-02-25

Applicant: BASF SE

Inventor： Thomas EHLIS ,  Karin SCHEIN-ALBRECHT ,  Mathieu BLANCHOT ,  Dennis KAUFHOLD ,  Sebastian WLOCH ,  Helmut KRONEMAYER

IPC: C07C227/42 ,  C07C229/52

CPC classification number: C07C227/42 ,  C07C229/52 ,  C07B2200/13

Abstract: The present invention relates to a process for isolating 2-(4′-diethylamino-2′-hydroxybenzoyl)benzoic acid hexyl ester with a high purity and low phthalic acid dialkyl ester content.

公开(公告)号：US20240109838A1

公开(公告)日：2024-04-04

申请号：US18265999

申请日：2021-12-16

Applicant: BASF SE

Inventor： Karin SCHEIN-ALBRECHT ,  Thomas EHLIS ,  Mathieu BLANCHOT ,  Dennis KAUFHOLD ,  Helmut KRONEMAYER ,  Sebastian WLOCH

IPC: C07C227/18 ,  C07C227/10 ,  C07C227/40 ,  C07C227/42 ,  C07C229/52

CPC classification number: C07C227/18 ,  C07C227/10 ,  C07C227/40 ,  C07C227/42 ,  C07C229/52

Abstract: The present invention relates to a process of manufacturing 2-(4′-diethylamino-2′-hydroxybenzoyl)benzoic acid hexyl ester having a Gardner value of 8.2 or less comprising adjusting the reaction mixture obtained by reacting 2-(4′-diethylamino-2′-hydroxybenzoyl)benzoic acid with n-hexanol to a pH of more than 7 followed by extracting at least once with an aqueous phase and adsorbing the dissolved 2-(4′-diethylamino-2′-hydroxybenzoyl)benzoic acid hexyl ester over at least two different adsorbents.

公开(公告)号：US20240025841A1

公开(公告)日：2024-01-25

申请号：US18265993

申请日：2021-12-16

Applicant: BASF SE

Inventor： Helmut KRONEMAYER ,  Sebastian WLOCH ,  Andreas MELZER ,  Mathieu BLANCHOT ,  Karin SCHEIN-ALBRECHT ,  Dennis KAUFHOLD ,  Thomas EHLIS

IPC: C07C227/42 ,  C07C227/16 ,  A61K8/41

CPC classification number: C07C227/42 ,  C07C227/16 ,  A61K8/411 ,  C07B2200/13

Abstract: The presently claimed invention relates to a method for obtaining crystalline diethylamino hydroxybenzoyl hexyl benzoate. Further, the presently claimed invention relates to crystalline diethylamino hydroxybenzoyl hexyl benzoate obtained by the method and to a cosmetic composition comprising crystalline diethylamino hydroxybenzoyl hexyl benzoate. The crystalline diethylamino hydroxybenzoyl hexyl benzoate obtained by the method of the presently claimed invention has a phthalic acid dihexyl ester (PSDHE) content in the range of 1 to 250 ppm.