公开(公告)号：US11633394B2

公开(公告)日：2023-04-25

申请号：US16962941

申请日：2019-01-17

申请人： Aurigene Oncology Limited

发明人： Dinesh Chikkanna ,  Vinayak V. Khairnar ,  Muralidhara Ramachandra ,  Leena Khare Satyam

IPC分类号： A61K45/06 ,  C07C237/24 ,  C07C275/26 ,  C07C311/11 ,  C07D205/04 ,  C07D207/16 ,  C07D211/58 ,  C07D211/72 ,  C07D231/56 ,  C07D261/04 ,  C07D295/215 ,  C07D333/28 ,  C07D401/04 ,  A61K31/496 ,  A61P35/00 ,  A61K31/17 ,  A61K31/439 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/495 ,  C07D471/08

摘要： The present invention relates to substituted alkynylene compounds represented by the compounds of formula (I), pharmaceutically acceptable salts and stereoisomers thereof. The present invention further provides the therapeutic uses of the compounds of formula (I) as anti-cancer agents.

公开(公告)号：US20230210847A1

公开(公告)日：2023-07-06

申请号：US18120149

申请日：2023-03-10

申请人： AURIGENE ONCOLOGY LIMITED

发明人： Dinesh CHIKKANNA ,  Vinayak V. Khairnar ,  Muralidhara Ramachandra ,  Leena Khare Satyam

IPC分类号： A61K31/496 ,  A61P35/00 ,  A61K31/17 ,  A61K31/439 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/495 ,  A61K45/06 ,  C07C237/24 ,  C07C275/26 ,  C07C311/11 ,  C07D205/04 ,  C07D207/16 ,  C07D211/58 ,  C07D211/72 ,  C07D231/56 ,  C07D261/04 ,  C07D295/215 ,  C07D333/28 ,  C07D401/04 ,  C07D471/08

CPC分类号： A61K31/496 ,  A61P35/00 ,  A61K31/17 ,  A61K31/439 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/495 ,  A61K45/06 ,  C07C237/24 ,  C07C275/26 ,  C07C311/11 ,  C07D205/04 ,  C07D207/16 ,  C07D211/58 ,  C07D211/72 ,  C07D231/56 ,  C07D261/04 ,  C07D295/215 ,  C07D333/28 ,  C07D401/04 ,  C07D471/08

摘要： The present invention relates to substituted alkynylene compounds represented by the compounds of formula (I), pharmaceutically acceptable salts and stereoisomers thereof. The present invention further provides the therapeutic uses of the compounds of formula (I) as anti-cancer agents.

公开(公告)号：US20240156814A1

公开(公告)日：2024-05-16

申请号：US18406841

申请日：2024-01-08

申请人： Aurigene Oncology Limited

发明人： Muralidhara Ramachandra ,  Leena Khare Satyam ,  Sanjita Sasmal ,  Susanta Samajdar

IPC分类号： A61K31/501 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K31/501 ,  A61P35/00 ,  G01N33/57434

摘要： The present invention provides a method of treating a disease or disorder with at least one SMARCA2/4 degrader, in a subject who are responders to such treatment based on the presence of tumor specific alterations described therein. The present invention also provides the methods for treating prostate cancer in the subjects who are likely to respond to treatment with SMARCA2/4 degraders.